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Zonisamide is an antiseizure drug chemically classified as a sulfonamide and unrelated to other antiseizure agents. The precise mechanism by which zonisamide exerts its antiseizure effect is unknown, although it is believed that the drug blocks sodium and T-type calcium channels , which leads to the suppression of neuronal hypersynchronization ...
[10] [11] By blocking sodium or calcium channels, antiepileptic drugs reduce the release of excitatory glutamate, whose release is considered to be elevated in epilepsy, but also that of GABA. [12] This is probably a side effect or even the actual mechanism of action for some antiepileptic drugs, since GABA can itself, directly or indirectly ...
Lacosamide, sold under the brand name Vimpat among others, is a medication used for the treatment of partial-onset seizures and primary generalized tonic-clonic seizures. [2] It is used by mouth or intravenously .
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There is some evidence that rufinamide can modulate the gating of voltage-gated sodium channels, [8] [9] a common target for antiepileptic drugs. [10] A recent study indicates subtle effects on the voltage-dependence of gating and the time course of inactivation in some sodium channel isoforms that could reduce neuronal excitability. [ 11 ]
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related to: zonisamide vs lacosamide 10 gram capsulegoodrx.com has been visited by 100K+ users in the past month
109 S High St #100, Columbus, OH · Directions · (614) 224-4261"About 50% of US physicians advise patients consult GoodRx." - Fortune