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Choleretics are substances that increase the volume of secretion of bile from the liver as well as the amount of solids secreted. [1]By stimulating the production of bile, the body is better able to release toxins and through acting as a natural laxative and improving detox capacity of Cells and Tissue (biology).
Bile acids comprise about 80% of the organic compounds in bile (others are phospholipids and cholesterol). [5] An increased secretion of bile acids produces an increase in bile flow. Bile acids facilitate digestion of dietary fats and oils. They serve as micelle-forming surfactants, which encapsulate nutrients, facilitating their absorption. [6]
Secondary bile acids increase intracellular production of reactive oxygen and reactive nitrogen species resulting in increased oxidative stress and DNA damage. [ 30 ] [ 31 ] As shown in the figure below, deoxycholate added to the diet of mice increased the level of 8-oxo-dG , an oxidative DNA damage, in the colonic epithelium of mice.
When these bacteria flourish, they produce substances called short-chain fatty acids (SCFAs) that regulate cholesterol production in the liver and suppress its release into the bloodstream.
Bile is secreted by the liver into small ducts that join to form the common hepatic duct. [4] Between meals, secreted bile is stored in the gallbladder. [5] During a meal, the bile is secreted into the duodenum (part of the small intestine) to rid the body of waste stored in the bile as well as aid in the absorption of dietary fats and oils. [5]
Bile (from Latin bilis), or gall, is a yellow-green/misty green fluid produced by the liver of most vertebrates that aids the digestion of lipids in the small intestine. In humans, bile is primarily composed of water, is produced continuously by the liver, and is stored and concentrated in the gallbladder.
Bile acid sequestrants are polymeric compounds that serve as ion-exchange resins. Bile acid sequestrants exchange anions such as chloride ions for bile acids. By doing so, they bind bile acids and sequester them from the enterohepatic circulation. The liver then produces more bile acids to replace those that have been lost.
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