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Gout in foot joints is most common, with gout often affecting the big toe joint. However, other joints can be affected as well, particularly those in the lower body. For example, gout in ankles or ...
Allopurinol is used to reduce urate formation in conditions where urate deposition has already occurred or is predictable. The specific diseases and conditions where it is used include gouty arthritis, skin tophi, kidney stones, idiopathic gout; uric acid lithiasis; acute uric acid nephropathy; neoplastic disease and myeloproliferative disease with high cell turnover rates, in which high urate ...
] The safety trial was conducted in over 6,000 patients with gout treated with either febuxostat or allopurinol. The primary outcome was a combination of heart-related death, non-deadly heart attack, non-deadly stroke, and a condition of inadequate blood supply to the heart requiring urgent surgery.
For people with hyperuricosuria and calcium stones, allopurinol is one of the few treatments that have been shown to reduce kidney stone recurrences. Allopurinol interferes with the production of uric acid in the liver. The drug is also used in people with gout or hyperuricemia (high serum uric acid levels). [103]
Drugs with other primary uses, that have known uricosuric properties, include losartan, [1] atorvastatin, and fenofibrate.Although these drugs may have significant uricosuric action, their other significant pharmacological actions in off-label use as a uricosuric requires careful assessment of the patient to achieve the most benefit and least risk.
Americans are obsessed with a white Christmas and all the trimmings – snow, icicles, sleigh rides, frost on windowpanes, cuddling up by the fire, mittens, the North Pole. Christmas is a ...
Gout is a form of inflammatory arthritis characterized by recurrent attacks of a single red, tender, hot, and swollen joint. [ 1 ] [ 2 ] Pain typically comes on rapidly, reaching maximal intensity in less than twelve hours. [ 3 ]
Texas flips 4-star CB Kade Phillips. Kade Phillips, the No. 7 cornerback of the class, backed off his LSU pledge on Tuesday night, committing to Texas before signing with the Longhorns on ...
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