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Keratin 20, often abbreviated CK20, is a protein that in humans is encoded by the KRT20 gene. [5] [6] [7]Keratin 20 is a type I cytokeratin.It is a major cellular protein of mature enterocytes and goblet cells and is specifically found in the gastric and intestinal mucosa.
Because the keratin-7 antigen is found in both healthy and neoplastic cells, antibodies to CK7 can be used in immunohistochemistry to distinguish ovarian and transitional cell carcinomas (staining positive) from colonic and prostate cancers (negative), respectively. It is commonly used together with CK20 when making such diagnoses. [8]
The subdomains V1 and V2 contain residues enriched by glycines and/or serines, the former providing the cytokeratin chain a strong insoluble character and facilitating the interaction with other molecules. These terminal domains are also important in defining the function of the cytokeratin chain characteristic of a particular epithelial cell type.
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The name is literally imprinted on Baltimore. A plaque at the entrance to the Family Center at the Greater Baltimore Medical Center reads: "Donated by Nicholas and Mary Mangione."
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Primary EMPD tests positive for CK7 but negative for CK20, whereas secondary is positive for both. [15] Lack of positivity for hormone receptors and HER2 protein is overexpressed meaning that the cells are dividing rapidly and can be indicate an aggressive and more recurrent disease. [citation needed]
Type II cytokeratins are encoded on chromosome 12q and encompasses: CK1, CK2, CK3, CK4, CK5, CK6, CK7 and CK8. Their molecular weight ranges from 52 kDa (CK8) to 67 kDa (CK18). Overall, keratin type 2 plays a crucial role in maintaining the strength and integrity of the skin, hair, and nails.