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Metronidazole, sold under the brand name Flagyl among others, is an antibiotic and antiprotozoal medication. [10] It is used either alone or with other antibiotics to treat pelvic inflammatory disease , endocarditis , and bacterial vaginosis . [ 10 ]
Although rosacea was first described by Guy de Chauliac in the 14th century and included Chaucer's The Canterbury Tales, [2] when the National Rosacea Society was founded in 1992 rosacea was still considered a rare disease, and its first approved treatment, topical metronidazole, received orphan drug designation by the U.S. Food and Drug Administration in the belief that fewer than 200,000 ...
Rosacea conglobata is a severe rosacea that can mimic acne conglobata, with hemorrhagic nodular abscesses and indurated plaques. [26] Phymatous rosacea is a cutaneous condition characterized by overgrowth of sebaceous glands. [11] Phyma is Greek for swelling, mass, or bulb, and these can occur on the face and ears. [26]: 693
The first prescription-strength retinoid acne treatment available over the counter, this La Roche-Posay gel helps clear and prevent blackheads, whiteheads, clogged pores and blemishes.
Consistency and viscosity affect the adhesion and retention property of the gel, and are important in ensuring the gel is retained at the site of application and effective delivery of the drug. [ 3 ] The ingredients in topical gel formulation can be broadly categorized into four types: gelator, solvent, drug, and excipients.
Metronidazole comes in various concentrations ranging from 0.75% to 2%. Higher concentrated metronidazole did not equate to shorter time to cure times. [27] If the perioral dermatitis was triggered by a topical steroid then pimecrolimus cream has been suggested as effective in improving symptoms. [8]
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