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Metastatic breast-cancer cells excrete lysophosphatidic acid (LPA) which binds to receptors on tumor cells, inducing cell proliferation and release of cytokines(IL-6 and IL-8, potent bone resorptive agents) and stimulating bone resorption. After the breast-cancer cells have left the primary tumor, they interact with the bone microenvironment ...
Disseminating cancer cells can proliferate or become dormant depending on the microenvironment and factors such as the ERK/p38 ratio. Dormancy is a stage in cancer progression where the cells cease dividing but survive in a quiescent state while waiting for appropriate environmental conditions to begin proliferation again. [1]
Bone metastasis, or osseous metastatic disease, is a category of cancer metastases that result from primary tumor invasions into bones.Bone-originating primary tumors such as osteosarcoma, chondrosarcoma, and Ewing sarcoma are rare; the most common bone tumor is a metastasis. [1]
This means that if breast cancer metastasizes to the lungs, the secondary tumor is made up of abnormal breast cells, not of abnormal lung cells. The tumor in the lung is then called metastatic breast cancer, not lung cancer. Metastasis is a key element in cancer staging systems such as the TNM staging system, where it represents the "M".
While the high-dose chemotherapy and bone marrow transplant treatment is known for its impact on breast cancer, the treatment is presently used to treat other types of cancer, including testicular cancer, neuroblastoma, multiple myeloma, and various types of leukemias and lymphomas, like Hodgkin and non-Hodgkin Lymphoma. [10]
The 52-year-old Beverly Hills 90210 alum reveals to People that her cancer has spread to her bones."I'm not done with living. ... health battle began in 2015 when she revealed her breast cancer ...
This is an accepted version of this page This is the latest accepted revision, reviewed on 3 March 2025. Cancer that originates in mammary glands Medical condition Breast cancer An illustration of breast cancer Specialty Surgical oncology Symptoms A lump in a breast, a change in breast shape, dimpling of the skin, fluid from the nipple, a newly inverted nipple, a red scaly patch of skin on the ...
Comedocarcinoma is a kind of breast cancer that demonstrates comedonecrosis, which is the central necrosis [1] of cancer cells within involved ducts. Comedocarcinomas are usually non-infiltrating and intraductal tumors, characterized as a comedo-type, high-grade ductal carcinoma in situ (DCIS).
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