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Cholestatic pruritus is the sensation of itch due to nearly any liver disease, but the most commonly associated entities are primary biliary cholangitis, primary sclerosing cholangitis, obstructive choledocholithiasis, carcinoma of the bile duct, cholestasis (also see drug-induced pruritus), and chronic hepatitis C viral infection and other forms of viral hepatitis.
The itching is typically mild-to-moderate in intensity. It may manifest as a tingling, crawling or burning sensation, and can develop even with normal liver function tests. It does not correlate with progression of liver disease, and may even improve or disappear as the disease advances.
Dysesthesia is distinct in that it can, but not necessarily, refer to spontaneous sensations in the absence of stimuli. In the case of an evoked dysesthetic sensation, such as by the touch of clothing, the sensation is characterized not simply by an exaggeration of the feeling, but rather by a completely inappropriate sensation such as burning.
Given its anterior position in the abdominal cavity and its large size, the liver is prone to gun shot wounds and stab wounds. [2] Its firm location under the diaphragm also makes it especially prone to shearing forces. [1] Common causes of this type of injury are blunt force mechanisms such as motor vehicle accidents, falls, and sports injuries.
Liver size can be enlarged, normal, or shrunken in people with cirrhosis. [35] As the disease progresses, the liver will typically shrink due to the result of scarring. [36] Jaundice is the yellowing of the skin. It can additionally cause yellowing of mucous membranes notably of the white of the eyes.
They have a direct toxic effect on the liver; cause inflammation of liver caused by and thereby impact lipid metabolism and fatty liver disease; and can translocate from the lungs to the liver. [46] Because particulate matter and carbon black are very diverse and each has different toxicodynamics, detailed mechanisms of translocation are not clear.
Here you can see a typical test where the first lactate threshold is at around 210-215 power output and their second lactate threshold is at 260-265.
A tumor can expand the size of the liver several times and consequent stretching of its capsule can cause aching pain in the right hypochondrium. Other causes of pain in enlarged liver are traction of the supporting ligaments when standing or walking, the liver pressing against the rib cage or pinching the wall of the abdomen, and straining the ...
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