Search results
Results from the WOW.Com Content Network
Ubiquitin-activating enzymes, also known as E1 enzymes, catalyze the first step in the ubiquitination reaction, which (among other things) can target a protein for degradation via a proteasome. This covalent bond of ubiquitin or ubiquitin-like proteins to targeted proteins is a major mechanism for regulating protein function in eukaryotic ...
A ubiquitin-activating enzyme, or E1, first activates the ubiquitin by covalently attaching the molecule to its active site cysteine residue. The activated ubiquitin is then transferred to an E2 cysteine. Once conjugated to ubiquitin, the E2 molecule binds one of several ubiquitin ligases or E3s via a structurally conserved binding region.
7324 22194 Ensembl ENSG00000170142 ENSMUSG00000021774 UniProt P51965 P52482 RefSeq (mRNA) NM_001202476 NM_003341 NM_182666 NM_009455 RefSeq (protein) NP_001189405 NP_003332 NP_872607 NP_003332.1 NP_033481 Location (UCSC) Chr 3: 23.81 – 23.89 Mb Chr 14: 4.14 – 4.19 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Ubiquitin-conjugating enzyme E2 E1 is a protein that in humans is ...
The P-type ATPases, also known as E 1-E 2 ATPases, are a large group of evolutionarily related ion and lipid pumps that are found in bacteria, archaea, and eukaryotes. [1] P-type ATPases are α-helical bundle primary transporters named based upon their ability to catalyze auto- (or self-) phosphorylation (hence P) of a key conserved aspartate residue within the pump and their energy source ...
Adenovirus early region 1A (E1A) is a gene expressed during adenovirus replication to produce a variety of E1A proteins. [1] It is expressed during the early phase of the viral life span.
It is an enzymatic cascade catalyzed by first UBA3 and NAE1, which form the NEDD8 activation enzyme (E1), then the NEDD8 conjugating enzyme UBE2M or UBE2F (E2), and finally the NEDD8 ligase E3, which will bind the substrate NEDD8 to the target protein. The target protein will then have its activity, localization and/or stability affected.
A ubiquitin ligase (also called an E3 ubiquitin ligase) is a protein that recruits an E2 ubiquitin-conjugating enzyme that has been loaded with ubiquitin, recognizes a protein substrate, and assists or directly catalyzes the transfer of ubiquitin from the E2 to the protein substrate. In simple and more general terms, the ligase enables movement ...
Ubiquitin-like modifier activating enzyme 1 (UBA1) is an enzyme which in humans is encoded by the UBA1 gene. [5] [6] UBA1 participates in ubiquitination and the NEDD8 pathway for protein folding and degradation, among many other biological processes.