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In humans, mitochondrial DNA (mtDNA) forms closed circular molecules that contain 16,569 [4] [5] DNA base pairs, [6] with each such molecule normally containing a full set of the mitochondrial genes. Each human mitochondrion contains, on average, approximately 5 such mtDNA molecules, with the quantity ranging between 1 and 15. [ 6 ]
Human mitochondrial DNA was the first significant part of the human genome to be sequenced. [4] This sequencing revealed that human mtDNA has 16,569 base pairs and encodes 13 proteins. As in other vertebrates, the human mitochondrial genetic code differs slightly from nuclear DNA. [5]
Each human cell contains approximately 100 mitochondria, giving a total number of mtDNA molecules per human cell of approximately 500. [35] However, the amount of mitochondria per cell also varies by cell type, and an egg cell can contain 100,000 mitochondria, corresponding to up to 1,500,000 copies of the mitochondrial genome (constituting up ...
Each human cell contains approximately 100 mitochondria, giving a total number of mtDNA molecules per human cell of approximately 500. [10] However, the amount of mitochondria per cell also varies by cell type, and an egg cell can contain 100,000 mitochondria, corresponding to up to 1,500,000 copies of the mitochondrial genome (constituting up ...
Mitochondrial DNA usually has 16,569 base pairs (the number can vary slightly depending on addition or deletion mutations) [24] and is much smaller than the human genome DNA which has 3.2 billion base pairs. Mitochondrial DNA is transmitted from mother to child, as it is contained in the egg cell.
The mtDNA control region is an area of the mitochondrial genome which is non-coding DNA. This region controls RNA and DNA synthesis. [1] It is the most polymorphic region of the human mtDNA genome, [2] with polymorphism concentrated in hypervariable regions. The average nucleotide diversity in these regions is 1.7%. [3]
Human mtDNA codes for 13 proteins, most of which are involved in oxidative phosphorylation (OXPHOS). The nuclear genome encodes the remaining mitochondrial proteins, which are then transported into the mitochondria. [2] The genomes of these organelles have become far smaller than those of their free-living predecessors.
Phylogenetic tree of haplogroups I (left) and W (right). Kya in the left scale bar stands for thousand years ago. This phylogenetic tree of haplogroup W subclades is based on the paper by Mannis van Oven and Manfred Kayser Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation [2] and subsequent published research.