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Further breakdown of the blood–brain barrier, in turn cause a number of other damaging effects such as swelling, activation of macrophages, and more activation of cytokines and other destructive proteins. Astrocytes can heal partially the lesion leaving a scar. These scars (sclerae) are the known plaques or lesions usually reported in MS.
Cerebral palsy, in which lesions (damaged areas) may impair motor coordination; Senile dementia, fronto-temporal dementia, and vascular dementia; Pick's disease, causes progressive destruction of nerve cells in the brain; Huntington's disease, and other genetic disorders that cause build-up of toxic levels of proteins in neurons
Brain herniation can cause severe disability or death. In fact, when herniation is visible on a CT scan , the prognosis for a meaningful recovery of neurological function is poor. [ 2 ] The patient may become paralyzed on the same side as the lesion causing the pressure, or damage to parts of the brain caused by herniation may cause paralysis ...
Registration of images at different points of time (e.g., one year apart) can show evidence of atrophy that otherwise at individual time points may be reported as normal. Many research groups have begun using techniques such as magnetic resonance spectroscopy , functional imaging , and cortical thickness measurements in an attempt to offer an ...
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Some plaques occur in the brain as a result of aging, but large numbers of plaques and neurofibrillary tangles are characteristic features of Alzheimer's disease. [5] The plaques are highly variable in shape and size; in tissue sections immunostained for Aβ, they comprise a log-normal size distribution curve, with an average plaque area of 400 ...
The cysts and cavities (cystic brain lesions) are more likely to be the result of destructive (encephaloclastic) cause, but can also be from abnormal development (malformative), direct damage, inflammation, or hemorrhage. [5] The cysts and cavities cause a wide range of physiological, physical, and neurological symptoms. [6]
Brain abscess (or cerebral abscess) is an abscess within the brain tissue caused by inflammation and collection of infected material coming from local (ear infection, dental abscess, infection of paranasal sinuses, infection of the mastoid air cells of the temporal bone, epidural abscess) or remote (lung, heart, kidney etc.) infectious sources.