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Sodium salicylate is a sodium salt of salicylic acid. It can be prepared from sodium phenolate and carbon dioxide under higher temperature and pressure. Historically, it has been synthesized by refluxing methyl salicylate ( wintergreen oil) with an excess of sodium hydroxide .
Salicylic acid has long been a key starting material for making acetylsalicylic acid (ASA or aspirin). [8] ASA is prepared by the acetylation of salicylic acid with the acetyl group from acetic anhydride or acetyl chloride. [17] ASA is the standard to which all the other non-steroidal anti-inflammatory drugs are compared. In veterinary medicine ...
The therapeutic effects of salicylic acids were first documented in 1763 by Edward Stone, with acetylsalicylic acid being synthesized by Felix Hoffmann, a chemist working under Bayer, in 1897. [4] Acetylsalicylic acid-derived salt compounds were first discovered in 1970, [5] and the synthesis of lysine acetylsalicylate was first documented in ...
Copper aspirinate can be prepared by several methods. In one route of preparation, an excess of acetylsalicylic acid is dissolved in aqueous sodium carbonate. Sodium hydroxide is not suitable for this purpose, because it will hydrolyse acetylsalicylic acid (ASA) into salicylic acid and sodium acetate. 2 HC 9 H 7 O 4 + Na 2 CO 3 → 2 NaC 9 H 7 ...
Aspirin is the genericized trademark for acetylsalicylic acid (ASA), a nonsteroidal anti-inflammatory drug (NSAID) used to reduce pain, fever, and inflammation, and as an antithrombotic. [10] Specific inflammatory conditions that aspirin is used to treat include Kawasaki disease , pericarditis , and rheumatic fever .
904L is an austenitic stainless steel.It is softer than 316L, [1] [2] and its molybdenum addition gives it superior resistance to localized attack (pitting and crevice corrosion) by chlorides and greater resistance reducing acids; in particular, its copper addition gives it useful corrosion resistance to all concentrations of sulfuric acid.
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Structure of COX-2 inactivated by Aspirin. In the active site of each of the two enzymes, Serine 516 has been acetylated. Also visible is the salicylic acid which has transferred the acetyl group, and the heme cofactor. There are at least two different cyclooxygenase isozymes: COX-1 (PTGS1) and COX-2 (PTGS2).