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Deletion on a chromosome. In genetics, a deletion (also called gene deletion, deficiency, or deletion mutation) (sign: Δ) is a mutation (a genetic aberration) in which a part of a chromosome or a sequence of DNA is left out during DNA replication.
Gene knockout by mutation is commonly carried out in bacteria. An early instance of the use of this technique in Escherichia coli was published in 1989 by Hamilton, et al. [2] In this experiment, two sequential recombinations were used to delete the gene.
In genetics and especially genetic engineering, deletion mapping is a technique used to find out the mutation sites within a gene. The principle of deletion mapping involves crossing a strain which has a point mutation in a gene, with multiple strains who each carry a deletion in a different region of the same gene.
A newer theory suggests that the selective pressure on the CCR5 Delta 32 mutation was caused by smallpox instead of the bubonic plague. [116] Malaria resistance: An example of a harmful mutation is sickle-cell disease, a blood disorder in which the body produces an abnormal type of the oxygen-carrying substance haemoglobin in the red blood cells.
Genetic erosion in agricultural and livestock is the loss of biological genetic diversity – including the loss of individual genes, and the loss of particular recombinants of genes (or gene complexes) – such as those manifested in locally adapted landraces of domesticated animals or plants that have become adapted to the natural environment in which they originated.
Indel (insertion-deletion) is a molecular biology term for an insertion or deletion of bases in the genome of an organism. Indels ≥ 50 bases in length are classified as structural variants. [1] [2] In coding regions of the genome, unless the length of an indel is a multiple of 3, it will produce a frameshift mutation.
Examples of organisms which have experienced genome reduction include species of Buchnera, Chlamydia, Treponema, Mycoplasma, and many others. Comparisons of multiple sequenced genomes of endosymbionts in multiple isolates of the same species and lineages have confirmed that even long-time symbionts are still experiencing ongoing gene loss and ...
Pages in category "Biology theories" The following 42 pages are in this category, out of 42 total. ... Cell theory; Chromosome theory of cancer; Contingency ...