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It usually manifests in 1–3 hours after the first dose of antibiotics as fever, chills, rigor, hypotension, headache, tachycardia, hyperventilation, vasodilation with flushing, myalgia (muscle pain), exacerbation of skin lesions and anxiety. The intensity of the reaction indicates the severity of inflammation.
It is used as a precursor in the industrial synthesis of doxycycline hyclate. [citation needed] It has been found to act as an agonist of the human pregnane X receptor ligand-binding domain and to induce CYP3A4 expression in vitro. [1]
Doxycycline can cause gastrointestinal upset. [70] [71] Oral doxycycline can cause pill esophagitis, particularly when it is swallowed without adequate fluid, or by persons with difficulty swallowing or impaired mobility. [72] Doxycycline is less likely than other antibiotic drugs to cause Clostridioides difficile colitis. [73]
Headache, back pain, or stomach pain are some of the most common types of psychogenic pain. [5] It is commonly accompanied by social rejection, broken heart, grief, lovesickness, regret, or other such emotional events. This pain can also be caused by psychological disorders such as anxiety and depression, which can affect the onset and severity ...
It increases the risk of sunburn under exposure to light from the sun or other sources. This may be of particular importance for those intending to take on vacations long-term doxycycline as a malaria prophylaxis. They may cause stomach or bowel upsets, and, on rare occasions, allergic reactions.
Nearly 20% of American adults reported having an anxiety disorder in the past year — and many are more likely to feel uneasy and anxious as the sun sets. Experts reveal the common triggers.
[15] [16] A family history of depression increases the chance of being diagnosed. [17] There are usually a combination of biological, psychological, and social factors that play into a person's depression. [2] [18] A major depressive episode can often follow acute stress in someone's life, such as the death of a loved one or being fired from a ...
Zepbound did more noticeable things for my mental health than any SSRI that I have ever taken. (GLP-1s including Zepbound have been studied to decrease risk of depression and anxiety.) For the ...
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