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Buprenorphine, sold under the brand name Subutex among others, is an opioid used to treat opioid use disorder, acute pain, and chronic pain. [18] It can be used under the tongue (sublingual), in the cheek (buccal), by injection (intravenous and subcutaneous), as a skin patch (transdermal), or as an implant.
Buprenorphine/naloxone, sold under the brand name Suboxone among others, is a fixed-dose combination medication that includes buprenorphine and naloxone. [3] It is used to treat opioid use disorder, and reduces the mortality of opioid use disorder by 50% (by reducing the risk of overdose on full-agonist opioids such as heroin or fentanyl).
[129] [130] While the risk of misuse or overdose is higher with buprenorphine alone compared to the buprenorphine/naloxone combination or methadone, its usage is linked to a decrease in mortality. [ 131 ] [ 7 ] Approved in the U.S. for opioid dependence treatment in 2002, [ 132 ] buprenorphine has since expanded in form, with the FDA approving ...
MPA shot [38] Depo Provera, the shot: 4 (1 in 25) 0.2 (1 in 500) Progestogen: Injection: 12 weeks: Testosterone injection for male (unapproved, experimental method) [39] Testosterone Undecanoate: 6.1 (1 in 16) 1.1 (1 in 91) Testosterone: Intramuscular Injection: Every 4 weeks: 1999 cervical cap and spermicide (replaced by second generation in ...
Women should speak to their doctor or healthcare professional before starting or stopping any medications while pregnant. [1] Drugs taken in pregnancy including over-the counter-medications, prescription medications, nutritional supplements, recreational drugs, and illicit drugs may cause harm to the mother or the unborn child.
The lowest optimal dose of buprenorphine is 8 mg. [8] Buprenorphine has fewer withdrawal symptoms upon discontinuation, lower risk for overdose, and lower potential for abuse; therefore, it is more effective for unsupervised treatment than methadone. [8] Opioid users can take fewer doses per week than methadone. [8]
If pregnancy is a high concern, using two methods at the same time is reasonable. [128] For example, two forms of birth control are recommended in those taking the anti-acne drug isotretinoin or anti-epileptic drugs like carbamazepine, due to the high risk of birth defects if taken during pregnancy. [130] [131]
There is a risk that the drug is toxic to fetuses throughout the second and third trimesters. Group 9 There is a risk that the drug causes prenatal complications or abnormalities. Group 10 There is a risk that the drug causes hormone specific action on the human fetus. Group 11 There is a known risk that the drug is a mutagen/carcinogen.