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Naturally occurring lutetium (71 Lu) is composed of one stable isotope 175 Lu (97.41% natural abundance) and one long-lived radioisotope, 176 Lu with a half-life of 37 billion years (2.59% natural abundance).
The US Food and Drug Administration (FDA) approved 177 Lu dotatate based primarily on evidence from one clinical trial, NETTER-1 of 229 participants with somatostatin-receptor positive midgut GEP-NETs. [15] Enrolled participants had tumors which could not be surgically removed and were worsening while receiving treatment with octreotide. [15]
Explanation of the US Classification System; Critique of the Codeword Compartment in the CIA, March 1977; DCID 3/29, Controlled Access Program Oversight Committee, 2 June 1995; ICD 1, Policy Directive for Intelligence Community Leadership, 1 May 2006; ICD 705, Sensitive Compartmented Information Facilities, 26 May 2010
Access to SCIFs is normally limited to those individuals with appropriate security clearances. [6] Non-cleared personnel in SCIFs must be under the constant oversight of cleared personnel and all classified information and material removed from view to prevent unauthorized access. [7]
Pure lutetium metal is very difficult to prepare. It is one of the rarest and most expensive of the rare earth metals with the price about US$10,000 per kilogram, or about one-fourth that of gold. [41] [42] Crushed minerals are treated with hot concentrated sulfuric acid to produce water-soluble sulfates of rare earths.
The most common side effects are anaemia (low red blood cell counts), thrombocytopenia (low blood platelet counts), leucopenia (low white blood cell counts), lymphopenia (low levels of lymphocytes, a particular type of white blood cell), nausea (feeling sick), vomiting and mild and temporary hair loss.
A tree of life, like this one from Charles Darwin's notebooks c. July 1837, implies a single common ancestor at its root (labelled "1").. A phylogenetic tree directly portrays the idea of evolution by descent from a single ancestor. [3]
Lutetium compounds are compounds formed by the lanthanide metal lutetium (Lu). In these compounds, lutetium generally exhibits the +3 oxidation state, such as LuCl 3, Lu 2 O 3 and Lu 2 (SO 4) 3. [1]