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2. FDA approves new type of non-opioid pain medication, 1st of ...

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   This is the first class of non-opioid pain medication approved to treat moderate to severe acute pain approved by the FDA in more than 20 years. FDA approves new type of non-opioid pain medication ...

3. FDA approves new pain medication as an alternative to opioids ...

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   Acute pain is something more than 80 million Americans fill prescriptions to treat each year, according to Vertex. As opposed to chronic pain, which can last well after an injury or illness has ...

4. Ethyl loflazepate - Wikipedia

   en.wikipedia.org/wiki/Ethyl_loflazepate

   Ethyl loflazepate also produces an active metabolite which is stronger than the parent compound. [9] Ethyl loflazepate was designed to be a prodrug for descarboxyloflazepate, its active metabolite. It is the active metabolite which is responsible for most of the pharmacological effects rather than ethyl loflazepate. [10]

5. Equianalgesic - Wikipedia

   en.wikipedia.org/wiki/Equianalgesic

   Acute use (1–3 days) yields a potency about 1.5× stronger than that of morphine and chronic use (7 days+) yields a potency about 2.5 to 5× that of morphine. Similarly, the effect of tramadol increases after consecutive dosing due to the accumulation of its active metabolite and an increase of the oral bioavailability in chronic use.

6. Macrogol - Wikipedia

   en.wikipedia.org/wiki/Macrogol

   Macrogol 4000, pharmaceutical quality. Macrogol 3350, often in combination with electrolytes, is used for short-term relief of constipation as well as for long-term use in constipation of various causes, including in multiple sclerosis and Parkinson's disease patients (an often-overlooked non-motor symptom) as well as constipation caused by pharmaceutical drugs such as opioids and ...

7. FDA approves opioid-free pain medication with 'no sign of ...

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   In 2023, more than five million Americans 12 and older reported a "prescription use disorder" within the past year, according to the Centers for Disease Control and Prevention (CDC).