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Compared to the risk of bleeding with warfarin use, direct factor Xa inhibitors have a higher risk of GI bleeding, but lower risk of bleeding in the brain. [2] Other side effects may include stomach upset , dizziness , anemia or increased blood levels of liver enzymes .
Dabigatran, sold under the brand name Pradaxa among others, is an anticoagulant used to treat and prevent blood clots and to prevent stroke in people with atrial fibrillation. [ 6 ] [ 7 ] Specifically it is used to prevent blood clots following hip or knee replacement and in those with a history of prior clots. [ 6 ]
Compared to warfarin it has fewer interactions with other medications. [13] It is a direct factor Xa inhibitor. [9] In 2007, Pfizer and Bristol-Myers Squibb began the development of apixaban as an anticoagulant. [14] Apixaban was approved for medical use in the European Union in May 2011, and in the United States in December 2012.
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The structure of apixaban, before adjusting the moiety's for maximum potency. Apixaban. The 13F moiety intermediate before apixaban was fully developed. During the SAR development of apixaban there were three groups that needed to be tested to attain maximum potency and bioavailability.
I compared six brands of frozen tater tots from the grocery store to find the best one.. The tots from Sonic and Ore-Ida were a little too plain for my taste. Alexia Foods' crispy seasoned potato ...
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109 S High St #100, Columbus, OH · Directions · (614) 224-4261