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Embryo culture until the blastocyst stage confers a significant increase in live birth rate per embryo transfer, and there is no evidence of a difference between the groups in cumulative pregnancy rates. [2] Transfer day 2 instead of day 3 after fertilization has no differences in live birth rate. [3]
Implantation bleeding occurs between 7 and 14 days after fertilization, [56] and is a small amount of light vaginal bleeding or spotting that can occur in early pregnancy due to the blastocyst penetrating the lining of the uterus during implantation.
However, it is unlikely to increase clinical pregnancy rates when performed in fresh embryos transferred to unselected women, to those without poor prognosis or to women of advanced maternal age. [2] Also, overall, there no evidence of a significant difference in live birth rate following assisted hatching compared with no assisted hatching.
The trophoblasts secrete fluid into the blastocoel. The resulting increase in size of the blastocyst causes it to hatch through the zona pellucida, which then disintegrates. [5] This process is called zona hatching and it takes place on the sixth day of embryo development, immediately before the implantation process. The hatching of the human ...
Day 1 of pregnancy Not pregnant: Not pregnant: Has sex and ovulates: 2 weeks pregnant Not pregnant: Not pregnant: Fertilization; cleavage stage begins [3] Day 15 [3] Day 1 [3] [4] Not pregnant: Implantation of blastocyst begins Day 20 Day 6 [3] [4] Day 0 Implantation finished Day 26 Day 12 [3] [4] Day 6 (or Day 0) Embryo stage begins; first ...
The parameters for evaluation at day 2-3: Number of cells and division rhythm: The optimal number of cells is 4 at day 2 and 8 at day 3 (A quality). In day 3 9-10 cells is B, >=10 is C (suboptimal) and <=4 is D (barely implant). A normal division rate is to double cell number each 24 hours.
Chance of fertilization by menstrual cycle day relative to ovulation [14] Pregnancy rates for sexual intercourse are highest during the menstrual cycle time from some 5 days before until 1 to 2 days after ovulation. [15] For optimal pregnancy chance, there are recommendations of sexual intercourse every 1 or 2 days, [16] or every 2 or 3 days. [17]
It was found that PZD led to a significantly higher rate of pregnancy (40.7% vs 15.4%), ongoing pregnancy (35.6% vs 11.5%), and implantation (18.1% vs 5.7%) than ZD. This suggests that using the mechanical method of PZD in blastomere biopsies for preimplantation genetic diagnosis may be more proficient than using the chemical method of ZD.