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Childhood-onset systemic lupus erythematosus (i.e., cSLE), also termed juvenile-onset systemic lupus erythematosus, juvenile systemic lupus erythematosus, and pediatric systemic lupus erythematosus, is a form of the chronic inflammatory and autoimmune disease, systemic lupus erythematosus (i.e., SLE), that develops in individuals up to 18 years old. [1]
This classification is based on the current scientific consensus and reflects the level of evidence supporting the autoimmune nature of the disorder. Lastly, the prevalence rate, specifically in the United States, is included to give a sense of how common each disorder is within the population.
Neuropsychiatric systemic lupus erythematosus or NPSLE refers to the neurological and psychiatric manifestations of systemic lupus erythematosus. SLE is a disease in which the immune system attacks the body's own cells and tissues. It can affect various organs or systems of the body.
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ACR score is a scale to measure change in rheumatoid arthritis symptoms. [1] It is named after the American College of Rheumatology . The ACR score is more often used in clinical trials than in doctor patient-relationships, as it allows a common standard between researchers.
Lupus nephritis is an inflammation of the kidneys caused by systemic lupus erythematosus (SLE) and childhood-onset systemic lupus erythematosus which is a more severe form of SLE that develops in children up to 18 years old; both are autoimmune diseases. [3] [4] It is a type of glomerulonephritis in which the glomeruli become inflamed.
A formula (typically a simple sum of all accumulated points) that calculates the score. A set of thresholds that helps to translate the calculated score into a level of risk, or an equivalent formula or set of rules to translate the calculated score back into probabilities (leaving the nominal evaluation of severity to the practitioner).
Lupus headache is a proposed, specific headache disorder in patients with systemic lupus erythematosus (SLE). [1] [2] Research shows that headache is a symptom commonly described by SLE patients —57% in one meta-analysis, ranging in different studies from 33% to 78%; [3] of which migraine 31.7% and tension-type headache 23.5%.