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Calciphylaxis, also known as calcific uremic arteriolopathy (CUA) or “Grey Scale”, is a rare syndrome characterized by painful skin lesions.The pathogenesis of calciphylaxis is unclear but believed to involve calcification of the small blood vessels located within the fatty tissue and deeper layers of the skin, blood clots, and eventual death of skin cells due to lack of blood flow. [1]
There is a small amount of evidence supporting the use of sodium thiosulfate to counteract calciphylaxis, the calcification of blood vessels that may occur in hemodialysis patients with end-stage kidney disease. [15] [16] However, it has been claimed that this treatment may cause severe metabolic acidosis in some patients. [17] [18]
Other side effects of gold-containing drugs include kidney damage, itching rash, and ulcerations of the mouth, tongue, and pharynx. Approximately 35% of patients discontinue the use of gold salts because of these side effects. Kidney function must be monitored continuously while taking gold compounds. [5]
Carbamazepine is an approved treatment for bipolar disorder and epileptic seizures, but it has side effects useful in treating attention-deficit hyperactivity disorder (ADHD), schizophrenia, phantom limb syndrome, paroxysmal extreme pain disorder, neuromyotonia, and post-traumatic stress disorder.
There are some recommendations for the clinical treatment for people who have complications related to Mönckeberg's arteriosclerosis. Specifically for people with underlying phosphate disorders, the use of phosphate binders , low-dose vitamin D, calcimimetics , magnesium, bisphosphonates , sodium thiosulfate , and aldosterone antagonists have ...
Calcinosis cutis is an uncommon condition marked by calcium buildup in the skin and subcutaneous tissues. Calcinosis cutis can range in intensity from little nodules in one area of the body to huge, crippling lesions affecting a vast portion of the body. [1]
2. Acute Kidney Injury. Some reports in a review supported by Novo Nordisk suggested that semaglutide may decrease the risk of kidney disease over the long term. But there were also a few reports ...
Statements in medication package inserts listing the frequency of side effects describe how often the effect occurs after taking a drug, but are not making any assertion that there is a causal connection between taking the drug and the occurrence of the side effect. In other words, what is being reported on is correlation, not necessarily ...