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This is due to depolarization of the muscle. Also, post-operative pain is associated with depolarizing blockers. The tetanic fade is the failure of muscles to maintain a fused tetany at sufficiently high frequencies of electrical stimulation. Non-depolarizing blockers have this effect on patients, probably by an effect on presynaptic receptors ...
Depolarizing neuromuscular blockers: Depolarizing neuromuscular blockers directly bind to postsynaptic cholinergic receptors of the neuromuscular junction to generate a sustained action potential. This causes prolonged stimulation and desensitization of neuroreceptors, causing skeletal muscle relaxation effects such as paralysis. [ 1 ]
Spasmolytics, also known as "centrally acting" muscle relaxant, are used to alleviate musculoskeletal pain and spasms and to reduce spasticity in a variety of neurological conditions. While both neuromuscular blockers and spasmolytics are often grouped together as muscle relaxant, [1] [2] the term is commonly used to refer to spasmolytics only ...
Pancuronium is a typical non-depolarizing curare-mimetic muscle relaxant. It competitively inhibits the nicotinic acetylcholine receptor at the neuromuscular junction by blocking the binding of acetylcholine. It has slight vagolytic activity, causing an increase in heart rate, but no ganglioplegic (i.e., blocking ganglions) activity.
Bupropion – Ganglion blocker [25] [26] [27] Dextromethorphan - Cough suppressant and ganglion blocker [28] [29] [30] Doxacurium – Nondepolarizing skeletal muscular relaxant; Hexamethonium – Ganglion blocker; Mecamylamine – Ganglion blocker and occasional smoking cessation aid [31] Tubocurarine - Nondepolarizing skeletal muscular relaxant
Phase 1 block does not show fade under tetanic stimulation. With further administration of depolarizing neuromuscular blocking agent, an effect that is similar to the response of muscle to non-depolarizing neuromuscular blocking agents can be observed. This response, termed phase 2 block, will demonstrate similar fade under tetanic stimulation ...
Rocuronium bromide is a competitive antagonist for the nicotinic acetylcholine receptors at the neuromuscular junction. Of the neuromuscular-blocking drugs it is considered to be a non-depolarizing neuromuscular junction blocker, because it acts by dampening the receptor action causing muscle relaxation, instead of continual depolarisation which is the mechanism of action of the depolarizing ...
Cholinergic blocking drugs are a group of drugs that block the action of acetylcholine (ACh), a neurotransmitter, in synapses of the cholinergic nervous system. [1] They block acetylcholine from binding to cholinergic receptors, namely the nicotinic and muscarinic receptors.