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Salicylic acid is an organic compound with the formula HOC 6 H 4 COOH. [3] A colorless (or white), bitter-tasting solid, it is a precursor to and a metabolite of acetylsalicylic acid (aspirin). [3] It is a plant hormone, [8] and has been listed by the EPA Toxic Substances Control Act (TSCA) Chemical Substance Inventory as an experimental ...
Aspirin (/ ˈ æ s p (ə) r ɪ n / [10]) is the genericized trademark for acetylsalicylic acid (ASA), a nonsteroidal anti-inflammatory drug (NSAID) used to reduce pain, fever, and inflammation, and as an antithrombotic. [11] Specific inflammatory conditions that aspirin is used to treat include Kawasaki disease, pericarditis, and rheumatic ...
Structure of COX-2 inactivated by Aspirin. In the active site of each of the two enzymes, Serine 516 has been acetylated. Also visible is the salicylic acid which has transferred the acetyl group, and the heme cofactor. There are at least two different cyclooxygenase isozymes: COX-1 (PTGS1) and COX-2 (PTGS2).
Most nonsteroidal anti-inflammatory drugs are weak acids, [155] with a pKa of 3–5. They are absorbed well from the stomach and intestinal mucosa. They are highly protein-bound in plasma (typically >95%), usually to albumin , so that their volume of distribution typically approximates to plasma volume.
The smaller the difference, the more the overlap. The case of citric acid is shown at the right; solutions of citric acid are buffered over the whole range of pH 2.5 to 7.5. According to Pauling's first rule, successive pK values of a given acid increase (pK a2 > pK a1). [28]
pK a values of amino acid side chains play an important role in defining the pH-dependent characteristics of a protein. The pH-dependence of the activity displayed by enzymes and the pH-dependence of protein stability, for example, are properties that are determined by the pK a values of amino acid side chains.
Copper aspirinate can be prepared by several methods. In one route of preparation, an excess of acetylsalicylic acid is dissolved in aqueous sodium carbonate. Sodium hydroxide is not suitable for this purpose, because it will hydrolyse acetylsalicylic acid (ASA) into salicylic acid and sodium acetate. 2 HC 9 H 7 O 4 + Na 2 CO 3 → 2 NaC 9 H 7 ...
The therapeutic effects of salicylic acids were first documented in 1763 by Edward Stone, with acetylsalicylic acid being synthesized by Felix Hoffmann, a chemist working under Bayer, in 1897. [4] Acetylsalicylic acid-derived salt compounds were first discovered in 1970, [5] and the synthesis of lysine acetylsalicylate was first documented in ...