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Dexmedetomidine, sold under the brand name Precedex among others, is a medication used for sedation. [4] Veterinarians use dexmedetomidine for similar purposes in treating cats, dogs, and horses. [ 10 ] [ 11 ] It is also used in humans to treat acute agitation associated with schizophrenia or bipolar disorder . [ 5 ]
The ICU method uses the Level of Service concept, in which reports on the amount of reserved capacity or capacity deficit. In order to calculate the Level of Service for the ICU method, the ICU for an intersection must be computed first. [3] ICU can be computed by: ICU = sum(max (tMin, v/si) * CL + tLi) / CL = Intersection Capacity Utilization
The dose range advised by the manufacturers is 20–40 μg/kg intravenous for moderate sedation, but this dose may need to be higher if given intramuscularly. When given intravenously, detomidine usually takes effect in 2–5 minutes, and recovery is full within 30–60 minutes.
Minimum alveolar concentration or MAC is the concentration, often expressed as a percentage by volume, of a vapour in the alveoli of the lungs that is needed to prevent movement (motor response) in 50% of subjects in response to surgical (pain) stimulus.
Medetomidine is a racemic mixture of two optical or stereoisomers, levomedetomidine and dexmedetomidine. [4] The latter causes the alpha 2- adrenergic agonist effects. [5] It is often used as the hydrochloride salt, medetomidine hydrochloride, a crystalline white solid that can be administered as an intravenous drug solution with sterile water.
Atipamezole is a competitive antagonist at ɑ 2-adrenergic receptors that competes with dexmedetomidine, an ɑ 2-adrenergic receptors agonist. It does not directly interact with dexmedetomidine; [34] rather, their structural similarity allows atipamezole to easily compete for receptor binding sites. [12]
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model to assess risk of death at ICU admission; has prediction models for assessment at admittance, 24h, 48h and 72h after; RIFLE - Risk, injury, failure, loss and end-stage kidney classification [2] has 3 severity levels (risk, injury and failure) and 2 possible outcomes (loss and end-stage) CP - Child–Pugh score [2] for patient with liver ...