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Estrogen dominance is widely discussed by many proponents and on many alternative medicine websites, including: Christiane Northrup , former obstetrics and gynecology physician, believes that estrogen dominance is linked to "allergies, autoimmune disorders, breast cancer, uterine cancer, infertility, ovarian cysts, and increased blood clotting ...
Estradiol affects target tissues mainly by interacting with two nuclear receptors called estrogen receptor α (ERα) and estrogen receptor β (ERβ). [ 36 ] [ 37 ] One of the functions of these estrogen receptors is the modulation of gene expression .
Estrogen is associated with edema, including facial and abdominal swelling. Melanin. Estrogen is known to cause darkening of skin, especially in the face and areolae. [38] Pale skinned women will develop browner and yellower skin during pregnancy, as a result of the increase of estrogen, known as the "mask of pregnancy". [39]
Estradiol, the prototypical estrogen. Steroid ring system. This is a list of steroidal estrogens or derivatives of estradiol, estrone, and estriol. Most esters of these estrogens are not included in this list; for esters, see here instead.
17α-Estradiol (also known as 17α-E2, 17-epiestradiol, alfatradiol, or estra-1,3,5(10)-triene-3,17α-diol) is a minor and weak endogenous steroidal estrogen that is related to 17β-estradiol (better known simply as estradiol). [2]
Estrogen glucuronides can be deconjugated into the corresponding free estrogens by β-glucuronidase in tissues that express this enzyme, such as the mammary gland. [2] As a result, estrogen glucuronides have estrogenic activity via conversion into estrogens. [2] Estradiol 3-glucuronide is a positional isomer of estradiol 17β-glucuronide
An estrogen conjugate is a conjugate of an endogenous estrogen. They occur naturally in the body as metabolites of estrogens and can be reconverted back into estrogens. They serve as a circulating reservoir for estrogen, particularly in the case of orally administered pharmaceutical estradiol .
2-Hydroxyestrone (2-OHE1), also known as estra-1,3,5(10)-trien-2,3-diol-17-one, is an endogenous, naturally occurring catechol estrogen and a major metabolite of estrone and estradiol. [ 1 ] [ 2 ] [ 3 ] It is formed irreversibly from estrone in the liver and to a lesser extent in other tissues via 2- hydroxylation mediated by cytochrome P450 ...
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