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Basic structure of a peroxisome Distribution of peroxisomes (white) in HEK 293 cells during mitosis Peroxisome in rat neonatal cardiomyocyte. A peroxisome (/ p ə ˈ r ɒ k s ɪ ˌ s oʊ m /) [1] is a membrane-bound organelle, a type of microbody, found in the cytoplasm of virtually all eukaryotic cells. [2] [3] Peroxisomes are oxidative ...
Peroxisomal disorders represent a class of medical conditions caused by defects in peroxisome functions. [1] This may be due to defects in single enzymes [2] important for peroxisome function or in peroxins, proteins encoded by PEX genes that are critical for normal peroxisome assembly and biogenesis.
Zellweger syndrome is a rare congenital disorder characterized by the reduction or absence of functional peroxisomes in the cells of an individual. [1] It is one of a family of disorders called Zellweger spectrum disorders which are leukodystrophies.
A toxicologist working in a lab (United States, 2008)Toxicology is a scientific discipline, overlapping with biology, chemistry, pharmacology, and medicine, that involves the study of the adverse effects of chemical substances on living organisms [1] and the practice of diagnosing and treating exposures to toxins and toxicants.
These DNA sequences are termed PPREs (peroxisome proliferator hormone response elements). The DNA consensus sequence is AGGTCANAGGTCA, with N being any nucleotide . In general, this sequence occurs in the promoter region of a gene , and, when the PPAR binds its ligand, transcription of target genes is increased or decreased, depending on the gene.
Karyn Hascal, The Healing Place’s president and CEO, said she would never allow Suboxone in her treatment program because her 12-step curriculum is “a drug-free model. There’s kind of a conflict between drug-free and Suboxone.” For policymakers, denying addicts the best scientifically proven treatment carries no political cost.
Returning to the Lincoln, Anderson joins her son in the backseat, squeezing her thin frame between the window and the cooler full of Pepsi cans. Fischer hugs a pillow and drifts off to sleep. We pass a 100-car coal train and cattle waiting to be fed. The long drive, Bob says, is “a small price to pay.” He wasn’t sure what to do about his ...
Substance intoxication is a transient condition of altered consciousness and behavior associated with recent use of a substance. [1] It is often maladaptive and impairing, but reversible. [2]