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2. Sildenafil - Wikipedia

   en.wikipedia.org/wiki/Sildenafil

   Sildenafil, sold under the brand name Viagra among others, is a medication used to treat erectile dysfunction and pulmonary arterial hypertension. [ 4 ] [ 8 ] It is also sometimes used off-label for the treatment of certain symptoms in secondary Raynaud's phenomenon . [ 9 ]

3. Things You Probably Don't Know About Viagra (Like What It Was ...

   www.aol.com/things-probably-dont-know-viagra...

   Sildenafil could also cause an increased risk of heart attack or other heart problems. If you have an irregular heartbeat, hearing loss, vision loss, an allergic reaction, Peyronie’s disease, or ...

4. Is Sildenafil Safe for This Common Male Problem? - AOL

   www.aol.com/sildenafil-safe-common-male-problem...

   Sildenafil is most commonly prescribed to be taken one time per day in doses between 25 and 100 mg for ED. Your healthcare provider will determine the best dosage for you based on a number of factors.

5. How to Take Viagra for Best Results - AOL

   www.aol.com/viagra-best-results-105700318.html

   Like other prescription medicines, Viagra and its generic form, sildenafil, work best when you take them under the right conditions. From your mental state to your eating habits, a range of ...

6. PDE5 inhibitor - Wikipedia

   en.wikipedia.org/wiki/PDE5_inhibitor

   Chemical structure of sildenafil (Viagra), the prototypical PDE5 inhibitor. A phosphodiesterase type 5 inhibitor (PDE5 inhibitor) is a vasodilating drug that works by blocking the degradative action of cGMP-specific phosphodiesterase type 5 (PDE5) on cyclic GMP in the smooth muscle cells lining the blood vessels supplying various tissues.

7. Discovery and development of phosphodiesterase 5 inhibitors

   en.wikipedia.org/wiki/Discovery_and_development...

   [1] [2] Sildenafil was initially introduced for clinical trial in 1989. It was the result of extensive research on chemical agents targeting PDE5 that could be effective in treatment of coronary heart disease. [22] Sildenafil did not prove effective for coronary heart disease but an interesting side effect was discovered, a penile erection.

8. What Does Viagra Actually Do to Your "Intimate" Experience? - AOL

   www.aol.com/does-viagra-actually-intimate...

   For example, a small study of 20 people that looked into Viagra’s effect on refractory time found that a standard 100mg dose of sildenafil citrate reduced the average male post-intimacy recovery ...

9. Vardenafil - Wikipedia

   en.wikipedia.org/wiki/Vardenafil

   Vardenafil's indications and contraindications are the same as with other PDE5 inhibitors; it is closely related in function to sildenafil citrate (Viagra) and tadalafil (Cialis). The difference between the vardenafil molecule and sildenafil citrate is a nitrogen atom's position and the change of sildenafil's piperazine ring methyl group to an ...