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Fexofenadine, sold under the brand name Allegra among others, [10] is an antihistamine pharmaceutical drug used in the treatment of allergy symptoms, such as hay fever and urticaria. [ 11 ] Therapeutically, fexofenadine is a selective peripheral H 1 blocker .
H 1 antagonists, also called H 1 blockers, are a class of medications that block the action of histamine at the H 1 receptor, helping to relieve allergic reactions. Agents where the main therapeutic effect is mediated by negative modulation of histamine receptors are termed antihistamines ; other agents may have antihistaminergic action but are ...
Histamine release in the brain triggers secondary release of excitatory neurotransmitters such as glutamate and acetylcholine via stimulation of H 1 receptors in the cerebral cortex. Consequently, unlike the H 1-antihistamines which are sedating, H 3-antihistamines have stimulant and cognition-modulating effects.
Here are the 3 copy and pastes from the article sections: (from introduction) Fexofenadine, like other second- and third-generation antihistamines, does not readily cross the blood–brain barrier, and so causes less drowsiness than first-generation histamine-receptor antagonists.
Terfenadine acts as a peripherally-selective antihistamine, or antagonist of the histamine H 1 receptor. [3] It is a prodrug, generally completely metabolized to the active form fexofenadine in the liver by the enzyme cytochrome P450 3A4. Due to its near complete metabolism by the liver immediately after leaving the gut, terfenadine normally is ...
There are several splice variants of H 3 present in various species. Though all of the receptors are 7-transmembrane g protein coupled receptors, H 1 and H 2 are quite different from H 3 and H 4 in their activities. H 1 causes an increase in PIP 2 hydrolysis, H2 stimulates gastric acid secretion, and H3 mediates feedback inhibition of histamine.
Teens aren't just sneaking quick glances at their phones during class.They're spending an average of 1.5 hours on them every school day, with 25% of students logging on for more than two hours ...
H 1-receptor antagonists are competitive inhibitor of histamine receptor H 1 and are used to treat allergies. This group is often referred simply as antihistamines . Wikimedia Commons has media related to H1 receptor antagonists .
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109 S High St #100, Columbus, OH · Directions · (614) 224-4261