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Serotonin syndrome (SS) is a group of symptoms that may occur with the use of certain serotonergic medications or drugs. [1] The symptoms can range from mild to severe, and are potentially fatal. [4] [5] [2] Symptoms in mild cases include high blood pressure and a fast heart rate; usually without a fever. [2]
The signs and symptoms of Serotonin Syndrome include: Agitation or restlessness. Insomnia. Dilated pupils. Loss of muscle coordination or twitching muscles. Muscle rigidity. Tremor. Heavy sweating ...
More severe symptoms include fever, seizures, irregular heartbeat, delirium, and coma. [76] [77] [11] If signs or symptoms arise, discontinue treatment with serotonergic agents immediately. [76] It is recommended to washout 4 to 5 half-lives of the serotonergic agent before using an MAO inhibitor. [78]
The observation of this efficacy led to the monoamine hypothesis of depression, which postulates that the deficit of certain neurotransmitters is responsible for depression, and even that certain neurotransmitters are linked to specific symptoms. Normal serotonin levels have been linked to mood and behaviour regulation, sleep, and digestion ...
Symptoms of Bipolar Disorder. The single most telling symptom of bipolar disorder is the episodic oscillation between high and low mood states — characteristic shifts between depression, normal ...
Alpha-blockers, like prazosin (Minipress®), are typically used to manage high blood pressure. These medications work by blocking the norepinephrine to help prevent blood vessels from tightening ...
The reason why serotonin levels are only high in dominant males, but not dominant females has not yet been established. [ 68 ] In humans, levels of 5-HT 1A receptor inhibition in the brain show negative correlation with aggression, [ 69 ] and a mutation in the gene that codes for the 5-HT 2A receptor may double the risk of suicide for those ...
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