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Type IV hypersensitivity, in the Gell and Coombs classification of allergic reactions, often called delayed-type hypersensitivity, is a type of hypersensitivity reaction that can take a day or more to develop. [1] Unlike the other types, it is not humoral (not antibody-mediated) but rather is a type of cell-mediated response.
If a person without a Kidd blood antigen (for example a Jka-Jkb+ patient) receives a Kidd antigen (Jka-antigen for example) in a red blood cell transfusion and forms an alloantibody (anti-Jka); upon subsequent transfusion with Jka-antigen positive red blood cells, the patient may have a delayed hemolytic transfusion reaction as their anti-Jka antibody hemolyzes the transfused Jka-antigen ...
Critical incidents are traumatic events capable of causing powerful emotional reactions in people who are exposed to those events. The most stressful of these are often seen as being line of duty deaths, co-worker suicide , multiple event incidents, delayed intervention and multi-casualty incidents. [ 4 ]
The ETI always occurs after the PTI pathway and DAMP release, and is a last resort response to the pathogen or trauma that ultimately results in programmed cell death. The PTI- and ETI-signaling pathways are used in conjunction with DAMPs to rapidly signal the rest of the plant to activate its innate immune response and fight off the invading ...
In transfusion medicine, transfusion-associated circulatory overload (aka TACO) is a transfusion reaction (an adverse effect of blood transfusion) resulting in signs or symptoms of excess fluid in the circulatory system (hypervolemia) within 12 hours after transfusion. [2]
Evidence-based, trauma-focused psychotherapy is the first-line treatment for PTSD. [1] [2] [3] Psychotherapy is defined as a treatment where a therapist and patient build a therapeutic relationship and focus on the patient's thoughts, attitudes, affect, behavior, and social development to lessen the patient's psychopathologies and functional impairment.
[7] [8] [9] Avoiding a trauma trigger, and therefore the potentially extreme reaction it provokes, is a common behavioral symptom of posttraumatic stress disorder (PTSD) and post-traumatic embitterment disorder (PTED), a treatable and usually temporary condition in which people sometimes experience overwhelming emotional or physical symptoms ...
There was a significant mechanism of injury (for example, a high-speed car accident, falls >20 ft); OR; The patient has an altered mental status; OR; The medical responder suspects that the patient has multi-systems trauma; If NONE of these criteria are met, the medical provider may go through a slower or more focused trauma assessment. [3]