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The vas deferens may be obstructed, or it may be completely absent in a condition known as congenital absence of the vas deferens (CAVD, a potential feature of cystic fibrosis), causing male infertility. Acquired obstructions can occur due to infections.
Vas deferens are less commonly palpated during routine a physical examination, hence the absence may go unnoticed. Also, injury to Vas deferens common in surgery. [1] Vas deferens may be absent on one or both sides, and in whole or in part. When only a part of Vas deferens is absent, it may fail to establish communication with the epididymis. [2]
Congenital bilateral absence of vas deferens: Males with congenital bilateral absence of the vas deferens most often have a mild mutation (a change that allows partial function of the gene) in one copy of the CFTR gene and a cystic fibrosis-causing mutation in the other copy of CFTR.
Cystic fibrosis (also known as CF or mucoviscidosis) is an autosomal recessive genetic disorder affecting most critically the lungs, and also the pancreas, liver, and intestine.
Vasography is an X-ray study of the vas deferens to see if there is blockage, oftentimes in the context of male infertility. [1] An incision is made in the scrotum, contrast is injected in the vas deferens, and X-rays are taken from different angles. [1] Thus, it is an invasive procedure and carries risk of iatrogenic scarring and obstruction ...
The spermatic cord is the cord-like structure in males formed by the vas deferens (ductus deferens) and surrounding tissue that runs from the deep inguinal ring down to each testicle. Its serosal covering, the tunica vaginalis, is an extension of the peritoneum that passes through the transversalis fascia. Each testicle develops in the lower ...
Congenital absence of the vas deferens; Cystic fibrosis transmembrane conductance regulator; Cystic fibrosis–related diabetes; D. ΔF508; Paul di Sant'Agnese;
Post-testicular azoospermia can be seen with certain point mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene commonly associated with congenital vas deferens abnormalities. [citation needed] Genetic counselling is indicated for men with genetic causes of azoospermia. In terms of reproduction, it needs to be ...