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A scale-down bioreactor is a miniature model designed to mimic or reproduce large-scale bio-processes or specific process steps on a smaller scale. These models play an important role during process development stage by fine-tuning the minute parameters and steps without the need for substantial investments in both materials and consumables.
The continuous stirred-tank reactor (CSTR), also known as vat-or backmix reactor, mixed flow reactor (MFR), or a continuous-flow stirred-tank reactor (CFSTR), is a common model for a chemical reactor in chemical engineering and environmental engineering. A CSTR often refers to a model used to estimate the key unit operation variables when using ...
General structure of a continuous stirred-tank type bioreactor. On the basis of mode of operation, a bioreactor may be classified as batch, fed batch or continuous (e.g. a continuous stirred-tank reactor model). An example of a continuous bioreactor is the chemostat. [citation needed]
The most familiar form of continuous reactor of this type is the continuously stirred tank reactor (CSTR). This is essentially a batch reactor used in a continuous flow. The disadvantage with a single stage CSTR is that it can be relatively wasteful on product during start up and shutdown.
[1] [2] Microcarrier cell suspensions in stirred tank bioreactors allows for an even distribution through homogenous stirring. [1] Parameters such as pH, oxygen pressure, and media supplement concentrations can be continually monitored within a bioreactor as opposed to manually testing small samples from plates. [ 2 ]
Stirred tank bioreactors are used for the biooxidation of gold. [16] While stirred tanks have been used to bioleach cobalt for copper mine tailings, [18] these are costly systems that can reach sizes of >1300m 3 meaning that they are almost exclusively used for very high value minerals like gold. [16] Illustration of the process of uranium heap ...
A single-use bioreactor or disposable bioreactor is a bioreactor with a disposable bag instead of a culture vessel. Typically, this refers to a bioreactor in which the lining in contact with the cell culture will be plastic, and this lining is encased within a more permanent structure (typically, either a rocker or a cuboid or cylindrical steel support).
A Continuous Oscillatory Baffled Reactor (COBR) is a specially designed chemical reactor to achieve plug flow under laminar flow conditions. Achieving plug flow has previously been limited to either a large number of continuous stir tank reactors (CSTR) in series or conditions with high turbulent flow.