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The nature of the host-pathogen interaction between humans and M. tuberculosis is considered to have a genetic component. A group of rare disorders called Mendelian Susceptibility to Mycobacterial Diseases (MSMD) was observed in a subset of individuals with a genetic defect that results in increased susceptibility to Mycobacterial infection.
The Mycobacterium tuberculosis complex (MTC or MTBC) is a genetically related group of Mycobacterium species that can cause tuberculosis in humans or other animals. It includes: Mycobacterium tuberculosis; Mycobacterium africanum; Mycobacterium orygis [1] Mycobacterium bovis and the Bacillus Calmette–Guérin strain; Mycobacterium microti ...
As of June 2006, 82 TB protein structures have been determined, 15 since January 1, 2006. The database of linked structural and functional information that has been constructed using this information can form a lasting basis for understanding M. tuberculosis pathogenesis and for structure-based drug design. [citation needed]
The ability to construct M. tuberculosis mutants and test individual gene products for specific functions has significantly advanced the understanding of its pathogenesis and virulence factors. Many secreted and exported proteins are known to be important in pathogenesis. [30]
M. tuberculosis is able to reproduce inside the macrophage and will eventually kill the immune cell. The primary site of infection in the lungs, known as the Ghon focus, is generally located in either the upper part of the lower lobe, or the lower part of the upper lobe. [13] Tuberculosis of the lungs may also occur via infection from the blood ...
Overexpression of G2 sRNA, for example, prevented growth of M. tuberculosis and greatly reduced the growth of M. smegmatis; ASdes sRNA is thought to be a cis-acting regulator of a fatty acid desaturase (desA2) while ASpks is found with the open reading frame for Polyketide synthase-12 (pks12) and is an antisense regulator of pks12 mRNA.
The medical history includes obtaining the symptoms of pulmonary TB: productive, prolonged cough of three or more weeks, chest pain, and hemoptysis.Systemic symptoms include low grade remittent fever, chills, night sweats, appetite loss, weight loss, easy fatiguability, and production of sputum that starts out mucoid but changes to purulent. [1]
[5] [6] [7] This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. Tbx2 and Tbx3 are the only T-box transcription factors that act as transcriptional repressors rather than transcriptional activators, and are closely related in terms of development and tumorigenesis. [ 8 ]