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Zaleplon is not recommended for chronic use in the elderly. [17] The elderly are more sensitive to the adverse effects of zaleplon such as cognitive side effects. Zaleplon may increase the risk of injury among the elderly. It should not be used during pregnancy or lactation.
They have largely been replaced by z-drugs (zopiclone, zolpidem) and atypical antidepressants (trazodone, mirtazapine) as first line treatment for insomnia. [8] Common side effects include drowsiness, motor and cognitive impairment, lethargy, confusion, euphoria, and dizziness. [8]
Eszopiclone, sold under the brand name Lunesta among others, is a medication used in the treatment of insomnia. [3] [4] Evidence supports slight to moderate benefit up to six months. [5] [4] [6] It is taken by mouth. [3] [5] Common side effects include headache, dry mouth, nausea, and dizziness. [5]
Chemical structure of the prototypical Z-drug zolpidem. Nonbenzodiazepines (/ ˌ n ɒ n ˌ b ɛ n z oʊ d aɪ ˈ æ z ɪ p iː n,-ˈ eɪ-/ [1] [2]), sometimes referred to colloquially as Z-drugs (as many of their names begin with the letter "z"), are a class of psychoactive, depressant, sedative, hypnotic, anxiolytic drugs that are benzodiazepine-like in uses, such as for treating insomnia [3 ...
In a mouse study, researchers found that zolpidem (Ambien), a common sleep aid, could prevent the brain from effectively clearing up 'waste', though it remains unclear whether this could affect ...
These side effects are serious and some of them are permanent, and many remain a crucial concern for companies and healthcare professionals and substantial efforts are being encouraged to reduce the potential risks for future antipsychotics through more clinical trials and drug development.
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