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A migrainous infarction is a rare type of ischaemic stroke which occurs in correspondence with migraine aura symptoms. [1] Symptoms include headaches, visual disturbances, strange sensations and dysphasia, all of which gradually worsen causing neurological changes which ultimately increase the risk of an ischaemic stroke. [2]
There are four possible phases of a migraine attack: prodrome, aura, attack and post-drome, the Mayo Clinic explains. Not everyone who gets a migraine attack will experience all four phases.
There are typical aura symptoms in addition to the brainstem symptoms during most attacks. Many patients who have attacks with brainstem aura also report other attacks with typical aura and should be coded for both 1.2.1 Migraine with typical aura and 1.2.2 Migraine with brainstem aura.
An aura is a perceptual disturbance experienced by some with epilepsy or migraine. An epileptic aura is actually a minor seizure. [1] Epileptic and migraine auras are due to the involvement of specific areas of the brain, which are those that determine the symptoms of the aura.
Scintillating scotoma is a common visual aura that was first described by 19th-century physician Hubert Airy (1838–1903). Originating from the brain, it may precede a migraine headache, but can also occur acephalgically (without headache), also known as visual migraine or migraine aura. [4]
Functional magnetic resonance imaging or functional MRI (fMRI) measures brain activity by detecting changes associated with blood flow. [1] [2] This technique relies on the fact that cerebral blood flow and neuronal activation are coupled. When an area of the brain is in use, blood flow to that region also increases.
Like in vivo MRS, fMRS can probe different nuclei, such as hydrogen (1 H) and carbon (13 C). The 1 H nucleus is the most sensitive and is most commonly used to measure metabolite concentrations and concentration dynamics, whereas 13 C is best suited for characterizing fluxes and pathways of brain metabolism.
The first study of the human brain at 3.0 T was published in 1994, [13] and in 1998 at 8 T. [14] Studies of the human brain have been performed at 9.4 T (2006) [15] and up to 10.5 T (2019). [16] Paul Lauterbur and Sir Peter Mansfield were awarded the 2003 Nobel Prize in Physiology or Medicine for their discoveries concerning MRI.
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