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Carcinoma of the tonsil is a type of squamous cell carcinoma. The tonsil is the most common site of squamous cell carcinoma in the oropharynx. It comprises 23.1% of all malignancies of the oropharynx. [1] The tumors frequently present at advanced stages, and around 70% of patients present with metastasis to the cervical lymph nodes. [2].
Oropharyngeal cancer, [1] [2] [3] also known as oropharyngeal squamous cell carcinoma and tonsil cancer, [1] is a disease in which abnormal cells with the potential to both grow locally and spread to other parts of the body are found in the oral cavity, in the tissue of the part of the throat that includes the base of the tongue, the tonsils, the soft palate, and the walls of the pharynx.
Lingual tonsils are covered externally by stratified squamous epithelium (nonkeratinized) that invaginates inward forming tonsillar crypts. Beneath the epithelium is a layer of lymphoid nodules containing lymphocytes. Mucous glands located at the root of the tongue are drained through several ducts into the crypts of the lingual tonsils.
The palatine tonsils are located in the isthmus of the fauces, between the palatoglossal arch and the palatopharyngeal arch of the soft palate.. The palatine tonsil is one of the mucosa-associated lymphoid tissues (MALT), located at the entrance to the upper respiratory and gastrointestinal tracts to protect the body from the entry of exogenous material through mucosal sites.
The connection between HPV-infection and oropharyngeal cancer is stronger in regions of lymphoepithelial tissue (base of tongue and palatine tonsils) than in regions of stratified squamous epithelium (soft palate and uvula). [19] Human herpesvirus-8 infection can potentiate the effects of HPV-16. [20]
1 pharyngeal tonsil (or "adenoid"), located on the roof of the nasopharynx, under the sphenoid bone. 2 tubal tonsils on each side, where each auditory tube opens into the nasopharynx; 2 palatine tonsils (commonly called "the tonsils") located in the oropharynx; lingual tonsils, a collection of lymphatic tissue located on the back part of the tongue
The tonsils are a set of lymphoid organs facing into the aerodigestive tract, which is known as Waldeyer's tonsillar ring and consists of the adenoid tonsil (or pharyngeal tonsil), two tubal tonsils, two palatine tonsils, and the lingual tonsils. These organs play an important role in the immune system.
Each tubal tonsil is located posterior to the opening of the Eustachian tube on the lateral wall of the nasopharynx. [1] It is one of the four main tonsil groups forming Waldeyer's tonsillar ring. [2] This ring also includes the palatine tonsils, the lingual tonsils, and the adenoid. [2]
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