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Diltiazem has negative inotropic, chronotropic, and dromotropic effects. This means diltiazem causes a decrease in heart muscle contractility – how strong the beat is, lowering of heart rate – due to slowing of the sinoatrial node , and a slowing of conduction through the atrioventricular node – increasing the time needed for each beat.
Drug-induced liver injury (DILI) is a cause of acute and chronic liver disease caused specifically by medications and the most common reason for a drug to be withdrawn from the market after approval. The liver plays a central role in transforming and clearing chemicals and is susceptible to the toxicity from these agents.
Over time, this can lead to another type of liver disease called NAFLD . While the cause isn’t 100% clear, it is often linked to overweight, obesity, type 2 diabetes , metabolic syndrome, high ...
Risk Factors for Fatty Liver Disease. Having overweight or obesity is a major risk factor for fatty liver disease. Estimates suggest that up to 75 percent of people with overweight have NAFLD, and ...
Fatty liver disease (FLD), also known as hepatic steatosis and steatotic liver disease (SLD), is a condition where excess fat builds up in the liver. [1] Often there are no or few symptoms. [ 1 ] [ 2 ] Occasionally there may be tiredness or pain in the upper right side of the abdomen . [ 1 ]
Fibrates may decrease LDL, though generally to a lesser degree than statins. Similar to statins, the risk of muscle damage exists. Niacin, like fibrates, is also well suited for lowering triglycerides by 20–50%. It may also lower LDL by 5–25% and increase HDL by 15–35%. Niacin may cause hyperglycemia and may also cause liver damage.
To slow or maybe even reverse organ damage linked to aging, scientists must first figure out what goes wrong at the cellular level. Duke University researchers are gaining ground on that quest ...
Alcoholic fatty liver disease is caused by drinking too much alcohol over an extended period of time. Risk Factors for Fatty Liver Disease Having overweight or obesity is a major risk factor for ...
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