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Cocaine increases alertness, feelings of well-being, euphoria, energy, sociability, and sexuality. The former are some of the desired effects of cocaine intoxication. Not having the normal use of mental faculties by reason of the introduction of cocaine is defined drug intoxication by the laws in America, Europe, and most of the rest of the World, and it is a serious crime in specific contexts ...
Cocaine dependence is a neurological disorder that is characterized by withdrawal symptoms upon cessation from cocaine use. [1] It also often coincides with cocaine addiction which is a biopsychosocial disorder characterized by persistent use of cocaine and/or crack despite substantial harm and adverse consequences.
Neuroscientists believe that drug addicts’ behavior is a direct correlation to some physiological change in their brain, caused by using drugs. This view believes there is a bodily function in the brain causing the addiction. This is brought on by a change in the brain caused by brain damage or adaptation from chronic drug use. [1] [2]
It’s a “delicate balance” finding effective treatments, Jordan said, noting that a drug for stimulant use disorders would ideally bring the brain back to its natural state without causing ...
These can be regulated by chronic cocaine treatment via D1 receptors, and all of the genes contain AP-1 transcriptional complex binding sites in their promoter regions. For extracellular signaling molecules, they looked at the expression of the genes IGFBP6 and SDF1. Both of these were induced in the caudate putamen in wild-type mice but ...
It can also cause headaches and gastrointestinal complications such as abdominal pain and nausea. A common but untrue belief is that the smoking of cocaine chemically breaks down tooth enamel and causes tooth decay. Cocaine can cause involuntary tooth grinding, known as bruxism, which can deteriorate tooth enamel and lead to gingivitis. [83]
This prevents proper retinal homeostasis and causes tissue injury. Over a long period, tissue damage accumulates and leads to tissue death or retinal infarction. [23] The duration of cocaine use is a major contributing factor to the severity of the adverse retinal effect. [24]
Existing treatments aim to suppress the immune system to prevent further damage to nerve cells. A new study has developed a treatment that can help regenerate myelin with the potential to stop and ...