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On 28 June 2013 FDA approved Brisdelle (low-dose paroxetine mesylate) for the treatment of moderate-to-severe vasomotor symptoms (e.g. hot flashes and night sweats) associated with menopause. Paroxetine became the first and only non-hormonal therapy for menopausal hot flashes approved by FDA. [29]
Hormone replacement therapy (HRT), also known as menopausal hormone therapy or postmenopausal hormone therapy, is a form of hormone therapy used to treat symptoms associated with female menopause. [ 1 ] [ 2 ] Effects of menopause can include symptoms such as hot flashes , accelerated skin aging, vaginal dryness , decreased muscle mass , and ...
Women with vasomotor symptoms during menopause seem to have an especially unfavorable cardiometabolic profile, [36] as well as women with premature onset of menopause (before 45 years of age). [37] These risks can be reduced by managing risk factors, such as tobacco smoking, hypertension, increased blood lipids and body weight. [38] [39]
Menopause is a natural biological process. For some, it happens in their 40s while others start later in life in their 50s (the average age is 51 in the United States, according to Mayo Clinic).
In women, low levels of estrogen may cause symptoms such as hot flashes, sleeping disturbances, decreased bone health, [3] and changes in the genitourinary system. Hypoestrogenism is most commonly found in women who are postmenopausal , have primary ovarian insufficiency (POI), or are presenting with amenorrhea (absence of menstrual periods ).
Image credits: pleezebfree According to Dr. Cynthia Abraham, an Ob-Gyn at the Icahn School of Medicine in New York, hot flashes affect as many as 8 in 10 menopausal women in the United States ...
One of the most common causes of night sweats in women over 40 is the hormonal changes related to menopause and perimenopause. [3] This is a very common occurrence during the menopausal transition years. Over 80% of women experience hot flashes, which may include excessive sweating, during menopause. [4]
Fezolinetant, sold under the brand name Veozah among others, is a medication used for the treatment of hot flashes (vasomotor symptoms) due to menopause. [5] [11] It is a small-molecule, orally active, selective neurokinin-3 (NK 3) receptor antagonist which is under development for the treatment of sex hormone-related disorders.