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The cost of sequencing a human genome is dropping rapidly, due to the continual development of new, faster, cheaper DNA sequencing technologies such as "next-generation DNA sequencing". The National Human Genome Research Institute, an arm of the U.S. National Institutes of Health , has reported that the cost to sequence a whole human-sized ...
Rothberg estimated the cost of the sequence—the first personal genome produced using a next-generation sequencing platform—at $1 million. [12] Watson's genome sequence was published in 2008. [13] A number of scientists have highlighted the cost of additional analysis after performing sequencing.
Genome sequencing became more cost-effective over time, and made it applicable in the medical field, allowing scientists to understand which genes are attributed to specific diseases. Personalized medicine is an emerging practice in medicine that develops patient-specific treatments based on an individual's genetic profile.
Veritas Genetics is a personal genomics startup based in Danvers, Massachusetts. [1] According to the company's press release, it was among the first companies to offer whole genome sequencing and interpretation for under $1,000. [2] It was co-founded in 2014 by George M. Church, Mirza Cifric, Preston Estep, and Jonathan Zhao. [3]
In June 2009, Illumina announced that they were launching their own Personal Full Genome Sequencing Service at a depth of 30× for $48,000 per genome. [60] [61] In August, the founder of Helicos Biosciences, Stephen Quake, stated that using the company's Single Molecule Sequencer he sequenced his own full genome for less than $50,000. [62]
The Carlson curve is a term to describe the rate of DNA sequencing or cost per sequenced base as a function of time. [1] It is the biotechnological equivalent of Moore's law. Carlson predicted that the doubling time of DNA sequencing technologies (measured by cost and performance) would be at least as fast as Moore's law. [2]
Celera Corporation is a subsidiary of Quest Diagnostics which focuses on genetic sequencing and related technologies. It was founded in 1998 as a business unit of Applera , spun off into an independent company in 2008, and finally acquired by Quest Diagnostics in 2011.
In recent years the development of high-throughput or next-generation sequencing has dramatically lowered the cost of DNA sequencing permitting laboratories to evaluate all 20,000 genes of the human genome at once through exome sequencing and whole genome sequencing. [9]
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