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Schematic of cell adhesion. Cell adhesion is the process by which cells interact and attach to neighbouring cells through specialised molecules of the cell surface. This process can occur either through direct contact between cell surfaces such as cell junctions or indirect interaction, where cells attach to surrounding extracellular matrix, a gel-like structure containing molecules released ...
These short amino acid sequences are the minimum motif of a larger protein that is necessary for binding to a cell surface receptor that drives cell adhesion. [40] The majority (89%) of published studies on biomaterials functionalized with cell adhesive peptides use RGD, whereas IKVAV and YIGSR are used in 6%, and 4% of those studies ...
] His research on focal adhesions includes the discovery of many adhesion proteins including vinculin, [2] [3] talin [4] [5] and paxillin, [6] [7] and ranks him in top 1% of the most cited scientist in the field of molecular biology and genetics. [1] Burridge has published more than 200 peer reviewed articles.
The process is highly regulated by cell adhesion molecules, particularly, the addressin also known as MADCAM1. This antigen is known for its role in tissue-specific adhesion of lymphocytes to high endothelium venules. [23] Through these interactions they play a crucial role in orchestrating circulating lymphocytes.
Synaptic cell adhesion molecules (CAMs) play a crucial role in axon pathfinding and synaptic establishment between neurons during neurodevelopment and are integral members in many synaptic processes including the correct alignment of pre- and post-synaptic signal transduction pathways, vesicular recycling in regards to endocytosis and exocytosis, integration of postsynaptic receptors and ...
The major cell-matrix adhesion receptors are integrins and therefore the adhesome of cell-matrix adhesion is referred to as the integrin adhesome. [4] Cell-cell adhesion is primarily mediated by cadherin receptors and therefore the adhesome of cell-cell adhesion is referred to as the cadherin adhesome or cadhesome. [5]
Cell Communication & Adhesion (formerly Cell Adhesion & Communication) is an academic journal that publishes review articles on intercellular communication, intercellular junctions and families of adhesion receptors and counter receptors from diverse biological systems.
A part of the cavin family, caleoles provide integral structure for the cell membrane and associates with lipids, such as cholesterol, and PIP2 to form lipid membrane rafts. In caveolar dynamin-dependent endocytosis, actin stress fibers and actin binding in response to a loss in cell adhesion help to internalize caveolae and its contents.