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Theophylline, also known as 1,3-dimethylxanthine, is a drug that inhibits phosphodiesterase and blocks adenosine receptors. [1] It is used to treat chronic obstructive pulmonary disease (COPD) and asthma . [ 2 ]
Progesterone is used as part of hormone replacement therapy in people who have low progesterone levels, and for other reasons. For purposes of comparison with normal physiological circumstances, luteal phase levels of progesterone are 4 to 30 ng/mL, while follicular phase levels of progesterone are 0.02 to 0.9 ng/mL, menopausal levels are 0.03 to 0.3 ng/mL, and levels of progesterone in men ...
Peak-to-trough ratio in pharmacokinetics is the ratio of peak (C max) and trough (C min) levels of a drug over its dosing interval (τ) at steady state.. Peak-to-trough ratio (PTR), also known as peak-to-trough variation or peak-to-trough fluctuation, is a parameter in pharmacokinetics which is defined as the ratio of C max (peak) concentration and C min (trough) concentration over a dosing ...
Short term drug side effects are most likely to occur at or near the C max, whereas the therapeutic effect of drug with sustained duration of action usually occurs at concentrations slightly above the C min. [citation needed] The C max is often measured in an effort to show bioequivalence (BE) between a generic and innovator drug product. [4]
A single oral dose of 10 mg MPA has been found to result in peak MPA levels of 1.2 to 5.2 ng/mL within 2 hours of administration using radioimmunoassay. [202] [203] Following this, levels of MPA decreased to 0.09 to 0.35 ng/mL 12 hours post-administration.
Dimenhydrinate is a theoclate salt composed of diphenhydramine and 8-chlorotheophylline (a theophylline relative) in a 1:1 ratio. [2] Dimenhydrinate was introduced to the market by G.D. Searle in 1949. [3] [4]
CINCINNATI − Biotech billionaire, former Republican presidential candidate and Cincinnati-area native Vivek Ramaswamy didn't always have nice things to say about his new cost-cutting co-worker ...
Peak levels of DHEA and DHEA-S are observed around age 20, which is followed by an age-dependent decline throughout life eventually back to prepubertal concentrations. [25] Plasma levels of DHEA in adult men are 10 to 25 nM, in premenopausal women are 5 to 30 nM, and in postmenopausal women are 2 to 20 nM. [ 25 ]