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It includes a collection of medical and patient information, access to Lexicomp drug monographs and drug-to-drug interactions, and a number of medical calculators. UpToDate is written by over 7,100 physician authors, editors, and peer reviewers. It is available both via the Internet and offline on personal computers or mobile devices.
When two drugs affect each other, it is a drug–drug interaction (DDI). The risk of a DDI increases with the number of drugs used. [1] A large share of elderly people regularly use five or more medications or supplements, with a significant risk of side-effects from drug–drug interactions. [2] Drug interactions can be of three kinds ...
Warfarin interacts with many commonly used drugs, and the metabolism of warfarin varies greatly between patients. [27] Some foods have also been reported to interact with warfarin. [27] Apart from the metabolic interactions, highly protein bound drugs can displace warfarin from serum albumin and cause an increase in the INR. [63]
The compilation is financially supported in part by pharmaceutical manufacturing corporations which create drugs listed within its pages. The 71st Edition, published in 2017, was the final hardcover edition. It weighed in at 4.6 pounds (2.1 kg) and contained information on over 1,000 drugs. [1]
E-prescribing systems can enhance an overall medication management process through clinical decision support systems that can perform checks against the patient's current medications for drug-drug interactions, drug-allergy interactions, diagnoses, body weight, age, drug appropriateness, and correct dosing.
Plant sterol-ester margarine and a common type of antihyperlipidaemic drug, cerivastatin, have an additive effect in reducing LDL cholesterol, without significant interaction between the two drugs. [28] Another drug combination with additive effect for hypercholesterolemia is niacin and simvastatin.
The first edition of The Merck Manual was published in 1899 by Merck & Co., Inc. for physicians and pharmacists and was titled Merck's Manual of the Materia Medica. [6] [7] The 192 page book which sold for US $1.00, was divided into three sections, Part I ("Materia Medica") was an alphabetical listing of all known compounds thought to be of therapeutic value with uses and doses; Part II ...
The following drugs can have negative interactions with rosuvastatin and should be discussed with the prescribing doctor: [14] [4] Coumadin anticoagulants ('blood thinners', e.g. warfarin) can affect the removal of rosuvastatin; Ciclosporin, colchicine
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