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Raloxifene is a selective estrogen receptor modulator (SERM) and therefore a mixed agonist–antagonist of the estrogen receptor (ER). [6] It has estrogenic effects in bone and antiestrogenic effects in the breasts and uterus. [6] Raloxifene was approved for medical use in the United States in 1997. [6] It is available as a generic medication.
Raloxifene belongs to the second-generation benzothiophene SERM drugs. It has a high affinity for the ER with potent antiestrogenic activity and tissue-specific effects distinct from estradiol. [21] Raloxifene is an ER agonist in bone and the cardiovascular system, but in breast tissue and the endometrium it acts as an ER antagonist.
Blood doping is the injection of red blood cells, related blood products that contain red blood cells, or artificial oxygen containers. This is done by extracting and storing one's own blood prior to an athletic competition, well in advance of the competition so that the body can replenish its natural levels of red blood cells, and subsequently injecting the stored blood immediately before ...
Estradiol/raloxifene (E2/RLX) is a tissue-selective estrogen complex (TSEC) which was studied for potential use in menopausal hormone therapy but was never marketed. [ 2 ] [ 1 ] [ 3 ] [ 4 ] [ 5 ] Today, E2/RLX is not generally used due to concerns of endometrial hyperplasia .
In India, elementary schools provide education from Class 1 to Class 8. The children in these classes are generally aged between 6 and 15 years. It is the next stage after kindergarten (Pre-Nursery, Nursery, Prep or Lower Kindergarten and Upper Kindergarten). The next stage after primary education is Middle School (Class 7th to 10th).
The study concluded that raloxifene caused fewer side-effects and less endometrial cancer than tamoxifen. [6] [7] Raloxifene was found to be more effective at preventing noninvasive breast cancer but less effective at preventing invasive breast cancer. [8]
Other medications in this class include tamoxifen and raloxifene, although both are not as effective as clomiphene and are thus less widely used for fertility purposes. [7] They are used in ovulation induction by inhibiting the negative feedback of estrogen at the hypothalamus.
[7] [8] It works by causing the release of GnRH by the hypothalamus, and subsequently gonadotropin from the anterior pituitary. [6] Clomifene was approved for medical use in the United States in 1967. [5] It is on the World Health Organization's List of Essential Medicines. [9] Its introduction began the era of assisted reproductive technology ...