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56626 Ensembl ENSG00000166169 ENSMUSG00000025218 UniProt Q9UGP5 Q9QUG2 Q9QXE2 RefSeq (mRNA) NM_001174084 NM_001174085 NM_001308382 NM_013274 NM_020032 NM_001330506 NM_001330507 RefSeq (protein) NP_001167555 NP_001167556 NP_001295311 NP_037406 NP_001334531 NP_001334532 NP_001334533 NP_001334535 NP_036178 NP_001317435 NP_001317436 NP_064416 Location (UCSC) Chr 10: 101.58 – 101.59 Mb Chr 19: 45 ...
Regulation of transcription in mammals. An active enhancer regulatory sequence of DNA is enabled to interact with the promoter DNA regulatory sequence of its target gene by formation of a chromosome loop. This can initiate messenger RNA (mRNA) synthesis by RNA polymerase II (RNAP II) bound to the promoter at the transcription start site of the ...
The words homozygous, heterozygous, and hemizygous are used to describe the genotype of a diploid organism at a single locus on the DNA. Homozygous describes a genotype consisting of two identical alleles at a given locus, heterozygous describes a genotype consisting of two different alleles at a locus, hemizygous describes a genotype consisting of only a single copy of a particular gene in an ...
Epigenetic modifications, such as DNA methylation and histone modifications, contribute to the regulation of sex-specific gene expression. In some cases, these modifications help maintain the cellular memory of sex identity throughout an organism's life.
Regulation of gene expression, or gene regulation, [1] includes a wide range of mechanisms that are used by cells to increase or decrease the production of specific gene products (protein or RNA). Sophisticated programs of gene expression are widely observed in biology, for example to trigger developmental pathways, respond to environmental ...
Balancing selection refers to a number of selective processes by which multiple alleles (different versions of a gene) are actively maintained in the gene pool of a population at frequencies larger than expected from genetic drift alone. Balancing selection is rare compared to purifying selection. [1]
When homozygous B-I parents are crossed to homozygous B', the resultant F1 offspring all display low pigmentation which is due to gene silencing of b1. [39] [47] Unexpectedly, when F1 plants are self-crossed, the resultant F2 generation all display low pigmentation and have low levels of b1 expression. Furthermore, when any F2 plant (including ...
Genetic purging is the increased pressure of natural selection against deleterious alleles prompted by inbreeding. [1]Purging occurs because deleterious alleles tend to be recessive, which means that they only express all their harmful effects when they are present in the two copies of the individual (i.e., in homozygosis).