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Specifically, TREM2 mRNA has 3 different isoforms containing 3 consistent exons, and 2 that vary between the isoforms. [14] TREM2 mRNA is most highly expressed in brain, lungs, adrenal glands, placenta, gall bladder, and colon. [12] The functions of TREM2 have been studied in mice with disruption or mutation of the mouse ortholog, Trem2. [15]
102 11487 Ensembl ENSG00000137845 ENSMUSG00000054693 UniProt O14672 O35598 RefSeq (mRNA) NM_001110 NM_001320570 NM_007399 RefSeq (protein) NP_001101 NP_001307499 NP_001101.1 NP_031425 Location (UCSC) Chr 15: 58.59 – 58.75 Mb Chr 9: 70.59 – 70.69 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse ADAM10 endopeptidase Identifiers EC no. 3.4.24.81 CAS no. 193099-09-1 Databases IntEnz ...
A normal mRNA starts and ends with sections that do not code for amino acids of the actual protein. These sequences at the 5′ and 3′ ends of an mRNA strand are called untranslated regions (UTRs). The two UTRs at their strand ends are essential for the stability of an mRNA and also of a modRNA as well as for the efficiency of translation, i ...
Trem-like transcript 1 protein is a protein that in humans is encoded by the TREML1 gene. [5] [6] [7]TREML1 is located in a gene cluster on chromosome 6 with the single Ig variable (IgV) domain activating receptors TREM1 (MIM 605085) and TREM2 (MIM 605086), but it has distinct structural and functional properties.
27403 Ensembl ENSG00000064687 ENSMUSG00000035722 UniProt Q8IZY2 Q91V24 RefSeq (mRNA) NM_019112 NM_033308 NM_013850 NM_001347081 RefSeq (protein) NP_061985 NP_001334010 NP_038878 Location (UCSC) Chr 19: 1.04 – 1.07 Mb Chr 10: 79.83 – 79.85 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse ATP-binding cassette sub-family A member 7 is a protein that in humans is encoded by the ABCA7 ...
Rudolph E. Tanzi. Rudolph Emile 'Rudy' Tanzi (born September 18, 1958) a professor of Neurology at Harvard University, vice-chair of neurology, director of the Genetics and Aging Research Unit, and co-director of the Henry and Allison McCance Center for Brain Health at Massachusetts General Hospital (MGH).
Mature messenger RNA, often abbreviated as mature mRNA is a eukaryotic RNA transcript that has been spliced and processed and is ready for translation in the course of protein synthesis. Unlike the eukaryotic RNA immediately after transcription known as precursor messenger RNA , [ 1 ] mature mRNA consists exclusively of exons and has all ...
The pre-mRNA processing at the 3' end of the RNA molecule involves cleavage of its 3' end and then the addition of about 250 adenine residues to form a poly(A) tail.The cleavage and adenylation reactions occur primarily if a polyadenylation signal sequence (5'- AAUAAA-3') is located near the 3' end of the pre-mRNA molecule, which is followed by another sequence, which is usually (5'-CA-3') and ...
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