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The aPTT-based APC resistance test involves a modified aPTT test performed in the presence and absence of activated protein C (APC). [1] [5] The ratio of these aPTT values is calculated and is called the APC sensitivity ratio (APCsr) or simply APC ratio (APCr). [1] [5] This ratio is inversely related to the degree of APC resistance. [7]
It involves a modified aPTT test performed in the presence and absence of APC. [7] [8] The ratio of these aPTT values is calculated and is called the APC sensitivity ratio (APCsr) or simply APC ratio (APCr). [7] [8] This ratio is inversely related to the degree of APC resistance. [9] The aPTT-based APC resistance test was developed in 1993. [8]
Clotting time is a general term for the time required for a sample of blood to form a clot, or, in medical terms, coagulate.The term "clotting time" is often used when referring to tests such as the prothrombin time (PT), activated partial thromboplastin time (aPTT or PTT), activated clotting time (ACT), thrombin time (TT), or Reptilase time.
Fresh normal plasma has all the blood coagulation factors with normal levels. If the problem is a simple factor deficiency, mixing the patient plasma 1:1 with plasma that contains 100% of the normal factor level results in a level ≥50% in the mixture (say the patient has an activity of 0%; the average of 100% + 0% = 50%). [3]
Thromboelastography (TEG) is a method of testing the efficiency of blood coagulation.It is a test mainly used in surgery and anesthesiology, although increasingly used in resuscitations in emergency departments, intensive care units, and labor and delivery suites.
The KCT test/control ratio of greater than or equal to 1.2 indicates that a defect is present. [4] If the test/control ratio is between 1.1 and 1.2, the test is equivocal. [4] A good way of expressing the result using mixes is to calculate the Rosner index. [10]
Laboratories usually calculate their own ranges, based on the method used and the results obtained from healthy individuals from the local population. Variability arises from differences in thrombin concentration, dilution of plasma, presence and/or concentration of calcium ions, as well as the influence of analyser type. [ 5 ]
The prothrombin time ratio is the ratio of a subject's measured prothrombin time (in seconds) to the normal laboratory reference PT. The PT ratio varies depending on the specific reagents used, and has been replaced by the INR. [3] Elevated INR may be useful as a rapid and inexpensive diagnostic of infection in people with COVID-19. [4]
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