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2. Glucagon-like peptide-1 - Wikipedia

   en.wikipedia.org/wiki/Glucagon-like_peptide-1

   The initial product GLP-1 (1–37) is susceptible to amidation and proteolytic cleavage, which gives rise to the two truncated and equipotent biologically active forms, GLP-1 (7–36) amide and GLP-1 (7–37). Active GLP-1 protein secondary structure includes two α-helices from amino acid position 13–20 and 24–35 separated by a linker region.

3. Roche To Ride Booming Obesity Treatment Market With ... - AOL

   www.aol.com/finance/roche-ride-booming-obesity...

   Thursday, Genentech, a unit of Roche Holdings AG (OTC:RHHBY), released results from the Phase 1b trial of CT-388, a dual GLP-1/GIP receptor agonist being developed for the treatment of obesity and ...

4. Roche joins race for obesity drugs with $2.7 billion Carmot deal

   www.aol.com/news/roche-enters-obesity-drug...

   Roche in October agreed to pay an initial $7.1 billion to Roivant and Pfizer for rights to a new inflammatory bowel disease drug, eyeing new therapeutic fields to offset falling oncology sales.

5. CT-388 - Wikipedia

   en.wikipedia.org/wiki/CT-388

   CT-388 is a "biased" dual GLP-1 and GIP receptor agonist/modulator with minimal to no beta-arrestin coupling at either receptor and is designed to be administered as once weekly subcutaneous injection. [1] In a 24-week trial participants averaged 18.8 percent placebo adjusted weight loss. The drug is developed by Roche/Genentech. [2] [3] [4]

6. Novo Nordisk and Eli Lilly Could Have a Big Rival in the GLP ...

   www.aol.com/novo-nordisk-eli-lilly-could...

   Roche trades at a much more attractive earnings multiple than Eli Lilly and Novo Nordisk, which have a lot of GLP-1-driven growth expectations priced into their current valuations.

7. GLP-1 receptor agonist - Wikipedia

   en.wikipedia.org/wiki/GLP-1_receptor_agonist

   Native GLP-1 is a peptide hormone with a half-life of two minutes because it is rapidly cleared by the enzyme dipeptidyl peptidase-4. [29] As a result, different GLP-1 agonist drugs are modified in various ways to extend the half-life, resulting in drugs that can be dosed multiple times per day, daily, weekly, or less often. [29]

8. What Are GLP-1 Medications & Who Should Use Them? Here ... - AOL

   www.aol.com/glp-1-medications-them-heres...

   What is a GLP-1 medication? GLP-1 medications are drugs that mimic the effects of the GLP-1 hormone, helping regulate blood sugar and reduce appetite. They are primarily used for managing type 2 ...

9. GLP1 poly-agonist peptides - Wikipedia

   en.wikipedia.org/wiki/GLP1_poly-agonist_peptides

   GLP1 poly-agonist peptides [1] are a class of drugs that activate multiple peptide hormone receptors including the glucagon-like peptide-1 (GLP-1) receptor.These drugs are developed for the same indications as GLP-1 receptor agonists—especially obesity, type 2 diabetes, and non-alcoholic fatty liver disease.