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Diphenoxylate is a centrally active opioid drug of the phenylpiperidine series that is used as a combination drug with atropine for the treatment of diarrhea. Diphenoxylate is an opioid and acts by slowing intestinal contractions ; the atropine is present to prevent drug abuse and overdose.
Diphenoxylate/atropine, also known as co-phenotrope and sold under the brand name Lomotil among others, is used to treat diarrhea. [ 2 ] [ 3 ] It is a fixed-dose combination of the medications diphenoxylate , as the hydrochloride, an antidiarrheal ; and atropine , as the sulfate, an anticholinergic . [ 1 ]
Antimotility agents are drugs used to alleviate the symptoms of diarrhea. These include loperamide (Imodium), bismuth subsalicylate (Pepto-Bismol), [1] diphenoxylate with atropine (Lomotil), and opiates such as paregoric, tincture of opium, codeine, and morphine.
For issues with bowel movements (fecal incontinence), you may be prescribed: Imodium (loperamide) for treating diarrhea and improving bowel control Medications containing diphenoxylate and ...
Not more than 2.5 milligrams of diphenoxylate and not less than 25 micrograms of atropine sulfate per dosage unit [3] [note 1] N/A Not more than 100 milligrams of opium per 100 milliliters or per 100 grams [3] [note 1] N/A Not more than 0.5 milligram of difenoxin and not less than 25 micrograms of atropine sulfate per dosage unit [4]
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It is the principal metabolite of diphenoxylate. [3] [4]: 558 It was first approved in the US in 1978 [5] and in 1980 in the former West Germany. [6]: 485 Difenoxin crosses the blood brain barrier and induces some euphoria; it is often sold with or administered with atropine to reduce the potential for abuse and overdose. [2]