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Norethisterone is a potent progestogen and binds to the PR with approximately 150% of the affinity of progesterone. [11] In contrast, its parent compounds, testosterone, nandrolone (19-nortestosterone), and ethisterone (17α-ethynyltestosterone), have 2%, 22%, and 44% of the relative binding affinity of progesterone for the PR. [57]
NETA is a progestin, or a synthetic progestogen, and hence is an agonist of the progesterone receptor, the biological target of progestogens like progesterone. [1] It has weak androgenic and estrogenic activity and no other important hormonal activity. [1] [8] The medication is a prodrug of norethisterone in the body. [9] [10]
A progestogen, also referred to as a progestagen, gestagen, or gestogen, is a type of medication which produces effects similar to those of the natural female sex hormone progesterone in the body. [1] A progestin is a synthetic progestogen. [1] Progestogens are used most commonly in hormonal birth control and menopausal hormone therapy. [1]
Estradiol and norethisterone acetate (Activella, Amabelz) – 1 mg / 0.5 mg; 0.5 mg / 0.1 mg; Ethinylestradiol and norethisterone acetate (FemHRT) – 25 μg / 0.5 mg; Estradiol/progesterone (TX-001HR), a combination of estradiol and progesterone in oil-filled capsules, is currently pending approval. [45]
Norethisterone enanthate (NETE), also known as norethindrone enanthate, is a form of hormonal birth control which is used to prevent pregnancy in women. [1] [2] [3] It is used both as a form of progestogen-only injectable birth control and in combined injectable birth control formulations.
However, progestogen-only pills, including dienogest, medroxyprogesterone acetate, norethisterone, and cyproterone, are also effective in treating symptoms (i.e., pain, excess uterine bleeding), reducing associated lesions, and improving patient quality of life.
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