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The Disabled-1 (Dab1) gene encodes a key regulator of Reelin signaling. Reelin is a large glycoprotein secreted by neurons of the developing brain, particularly Cajal-Retzius cells . DAB1 functions downstream of Reln in a signaling pathway that controls cell positioning in the developing brain and during adult neurogenesis .
The spontaneous autosomal recessive scrambler mutation on chromosome 4 causes a deficiency of DAB1, encoding disabled-1, a protein involved in the signaling of the Reelin protein, lacking in the reeler mutant, [3] Dab1-scm homozygous mutants possess a reeler-like phenotype with respect to cell malpositioning in cerebellar cortex, hippocampus, and neocortex.
5649 19699 Ensembl ENSG00000189056 ENSMUSG00000042453 UniProt P78509 Q60841 RefSeq (mRNA) NM_173054 NM_005045 NM_011261 NM_001310464 RefSeq (protein) NP_005036 NP_774959 NP_001297393 NP_035391 Location (UCSC) Chr 7: 103.47 – 103.99 Mb Chr 5: 22.09 – 22.55 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Reelin, encoded by the RELN gene, is a large secreted extracellular matrix ...
1. Search your inbox for the subject line 'Get Started with AOL Desktop Gold'. 2. Open the email. 3. Click Download AOL Desktop Gold or Update Now. 4. Navigate to your Downloads folder and click Save. 5. Follow the installation steps listed below.
The AOL Desktop Gold Download Manager allows you to access a list of your downloaded files in one convenient location. Use the Download Manager to access and search downloads, sort downloads, web search similar items, and more. Open the Download Manager to access a download
DAB2 mRNA is expressed in normal ovarian epithelial cells but is down-regulated or absent from ovarian carcinoma cell lines. The 770-amino acid predicted protein has an overall 83% identity with the mouse p96 protein, a putative mitogen-responsive phosphoprotein; homology is strongest in the amino-terminal end of the protein in a region corresponding to the phosphotyrosine interaction domain.
AOL Tech Fortress is supported on Windows: Microsoft Windows 7 SP1 or later. One PC per purchase. Minimum configuration of 1GB RAM and 100 megabytes of free hard disk space, 1.80 GHz or faster 2 cores and x86/x64 compatible architectures. Also compatible with Windows Surface Pro and Surface Pro 2 tablets.
On 11 January 2012, two Dutch Internet service providers (Ziggo and XS4ALL) were ordered by a court in The Hague to disable lookups of The Pirate Bay's domain names and to block access to The Pirate Bay's IP addresses. [80] They started doing so on 31 January 2012. Pending the results of the appeal they needed to comply the court order.